В статье приводятся результаты генетического скрининга 76 быков производителей голштинской породы племенных центров №1, №2 и 200 коров зарубежной селекции племенного хозяйства ТОО «Байсерке-Агро». Генотипирование животных проведено по локусам следующих генов: GART, TFB1M, APOB, детерминирующих генетические аномалии, гаплотипов фертильности: HH4, HH5, HCD. Для выявления гетерозиготных носителей ...

PURPOSE This phase II open-label study evaluated the effect of concurrent or sequential administration of abiraterone acetate plus prednisone (AA + P) on sipuleucel-T manufacture and immune responses in metastatic castration-resistant prostate cancer (mCRPC) patients. EXPERIMENTAL DESIGN mCRPC patients received sipuleucel-T followed by AA + P 1 day (concurrent) or 10 weeks (sequential) after ...

PCR-based rye (Secale cereale L.) chromosome-specific markers can contribute to the effective utilization of elite genes of rye in wheat (Triticum aestivum L.) breeding programs. In the present study, 578 new PCR-based rye-specific markers have been developed by using specific length amplified fragment sequencing (SLAF-seq) technology, and 76 markers displayed different polymorphism among rye K...

In this work, we introduce a straightforward approach for bounding the regret of Multi-Objective Multi-Armed Bandit (MO-MAB) heuristics extended from standard bandit algorithms. The proposed methodology allows us to easily build upon the regret analysis of the heuristics in the standard bandit setting. Using our approach, we improve the Pareto UCB1 algorithm, that is the multi-objective extensi...

with the replacement of A1298C wild-type reverse primer with A1298C mutant reverse primer, which had the following sequence: 5 -GGTAAAGAACAAAGACTTCAAAGACACTGTG-3 (Sigma-Aldrich). ARMS PCR conditions were 95 °C for 5 min; 40 cycles of 95 °C for 30 s, 57 °C for 30 s, and 72 °C for 30 s; and 72 °C for 5 min. The wild-type reaction produces a 120-bp product, whereas the mutant reaction produces a 1...

Feline infectious peritonitis (FIP) is an immune-mediated, highly lethal disease caused by feline coronavirus (FCoV) infection. Currently, no protective vaccine or effective treatment for the disease is available. Studies have found that some cats survive the challenge of virulent FCoV isolates. Since cellular immunity is thought to be critical in preventing FIP and because diseased cats often ...

We study the {0, 1}-loss version of adaptive adversarial multi-armed bandit problems with α(≥ 1) lossless arms. For the problem, we show a tight bound K − α − Θ(1/T ) on the minimax expected number of mistakes (1-losses), where K is the number of arms and T is the number of rounds.

In IMpassion050 (NCT03726879), adding atezolizumab (A) to neoadjuvant chemotherapy (CT) and pertuzumab–trastuzumab (PH) did not increase pathological complete response (pCR) vs placebo (Pl), CT PH in patients (pts) with high-risk, HER2-positive (+) early breast cancer (EBC) either the intention-to-treat or PD-L1+ populations. Additional BM data are warranted better inform future immunotherapeut...