Mammalian expression systems, due to their capacity in post-translational modification, are preferred systems for biopharmaceutical protein production. Several recombinant protein systems have been introduced to the market, most of which are under clinical development. In spite of significant improvements such as cell line engineering, introducing novel expression methods, gene silencing and pr...

Organizational knowledge resources typically exist in specialized pockets scattered across the firm. As distributed knowledge systems, firms’ capacity to manage their knowledge resources is linked with their ability to integrate these pockets of specialized knowledge. Firms are increasingly depending on teams to strategically consolidate their dispersed knowledge into productive outcomes. Teams...

Demands for time, cost and clearness for mechatronics system design process has been significantly increased during last years. At the same time new methods are developed or are under the development to satisfy these needs. This paper represents the integration of two novel approaches for advanced mechatronics system design. A case study is composed.

Historically, systems integration was largely a technical and an operational task. It was considered as part of the wider area of systems engineering. However, in the last decade or so systems integration is considered to be a strategic enabler across different levels of the business such as systems engineering and operations, and is seen as critical in assisting senior management decision making.

Organizational knowledge resources typically exist in specialized pockets scattered across the firm. As distributed knowledge systems, firms’ capacity to manage their knowledge resources is linked with their ability to integrate these pockets of specialized knowledge. Firms are increasingly depending on teams to strategically consolidate their dispersed knowledge into productive outcomes. Teams...

the share of dc-based renewable energy resources (rers) and electricity storage systems are increasing due to developments of smart grid technologies. moreover, the share of dc-based load has rapid growth due to significant developments of power electronic technologies. therefore, a more flexible power system is required for efficient integration of emerging loads and generators. in this paper,...

................................................................ iii ACKNOWLEDGMENTS ..................................................... iv LIST OF FIGURES.......................................................... vii ACRONYMS................................................................................................ viii CHAPTERS