Background: The interaction between nervous and immune systems has been under investigation. Transient receptor potential vanilloid type 1(TRPV1) is a ligand gated calcium channel expressed by sensory neurons which mediates neurogenic inflammatory response. Substance p which can be released following exposure to capsaicin is a TRPV1 inducer, shown to have altered concentration and function in m...

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which is characterized by B-cell abnormality and auto-antibody generation. Since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with SLE. Objective: To investigate humoral immunity and specific-antibody formation in response to a...

OBJECTIVES To describe disease characteristics and treatment regimens for adult patients with systemic lupus erythematosus (SLE) with autoantibody positive disease in three countries (the Russian Federation, Ukraine and Republic of Kazakhstan). METHODS The Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q wave Coronary Events (ESSENCE) study was a 1-year, retrospective, multicentre, obs...

Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that affects multiorgan systems. Lupus nephritis is one of the most severe manifestations of SLE whereby immune-mediated inflammation can lead to permanent damage within the glomerular, tubulo-interstitial, and vascular compartments of the kidney, resulting in acute or chronic renal failure. The mechanisms that regulate host i...

Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, induced lupus-like symptoms. Eight months later, TG spontaneously developed typical SLE sym...

This review1 provided a comprehensive update on recent developments in systemic lupus erythematosus (SLE) and proposed several new viewpoints. In terms of diagnosis, the authors were first to put forward two types clinical SLE, addition classified SLE. Particularly, European League Against Rheumatism (EULAR)/American College Rheumatology score <10 category figure 4, suggested that an immunologi...

The "Euro-Lupus Cohort" is composed by 1000 patients with systemic lupus erythematosus (SLE) that have been followed prospectively since 1991. These patients have been gathered by a European consortium--the "Euro-Lupus Project Group". This consortium was originated as part of the network promoted by the "European Working Party on SLE", a working group created in 1990 in order to promote researc...

Renal involvement in systemic lupus erythematosus (SLE) is a typical manifestation of the disease. The occurrence of non-lupus nephritis in SLE patients has rarely been reported; we describe the case of a woman suffering from SLE and IgA nephropathy (IgAN). Although IgAN and lupus nephritis share some common physiopathological characteristics, their laboratory and histopathologic findings and t...

Correspondence to Professor Andrew G Franks Jr; [email protected] The expansion of genetic, genomic, environmental and metabolic knowledge that contributes to the immunological dysregulation in lupus is extremely challenging to those attempting to establish a ‘gold standard’ classification of systemic lupus erythematosus (SLE). An approach that incorporates this information into its class...

Objective In the recent months, there have been several case reports and series on COVID-19 in patients with systemic lupus erythematosus(SLE). We conducted a pooled analysis systematic review to summarise findings of these articles. Besides, we aimed determine predictors severe infection SLE by comparing mild moderate cases critical ones. Method All pertaining were retrieved from Pubmed, Wiley...