BACKGROUND Idiopathic systemic capillary leak syndrome (ISCLS) is a rare disorder, characterized by episodic life-threatening hypotension, hypoalbuminemia, and hemoconcentration. CASE PRESENTATION A 10-year-old girl presented with abdominal pain, vomiting, diarrhea, fever and developed generalized edema a day after admission. Clinical and laboratory findings were consistent with ISCLS. She re...

An extremely rapid on-chip separation of DNA from its single-base substituted mutant is described. By using affinity capillary electrophoresis (ACE) in a poly(dimethylsiloxane) (PDMS)-glass hybrid microdevice, we achieved the separation within 5 s.

Pulmonary oedema due to pulmonary capillary leak syndrome during the use of cyclosporin, particularly when given intravenously, has been reported in some patients after bone marrow, liver, and renal transplantation [1-4]. Suggested explanations for this effect have been a local high concentration of the drug in the pulmonary vessels when infused through a central line [3], or the solvent polyox...

A 32-year-old woman, pregnant with twins, presented with a chief complaint of general fatigue. Her general condition had rapidly deteriorated since her last visit to the primary obstetrician; the patient was then referred to our hospital because of suspected fetal death. She underwent emergency cesarean section because fetal death had indeed occurred, and she was then admitted to the intensive ...

Percutaneous closure of a prosthetic paravalvular leak (PVL) is a challenging procedure. Operators must use devices constructed for other applications. We present the use of a device which is specifically designed for PVL closure. To the best of our knowledge, there is no publication in MEDLINE reporting the use of the device.

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The core of biological agents recently introduced in human therapy includes Monoclonal Antibodies, Fusion proteins and a number of Cytokines employed in monotherapy or in association with conventional drugs. Their extraordinary impact in oncologic, autoimmune, and inflammatory diseases is impressive. However, they are usually accompanied by a complex profile of Drug-Related Adverse Events (DRAE...