Physiol. Soc.. ESSN: 1548-9221. Visit our website at http://www.the-aps.org/. Sci./Am. American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. © 2007 Int. Union Physiol. the physiological developments. It is published bimonthly in February, April, June, August, October, and December by (formerly published as News in Physiological Science) publishes brief review articles on ...

Retinal waves promote synapse development 1 1 2 3

The main hallmarks of Alzheimer's disease (AD) are extracellular deposits of amyloid plaques and intracellular accumulation of hyperphosphorylated neurofibrillary tangles (tau). However, the mechanisms underlying these neuropathological changes remain largely unclear. To date, plenty of studies have shown that microglia-mediated neuroinflammation contributes to the pathogenesis of AD, and the m...

The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. Initially, T cell receptor ligands were engaged i...

In this paper, we present a context-aware service platform called Synapse and its simple smart home test bed. By exploiting the recorded histories of contexts and services, Synapse can learn different users’ habits. Then Synapse can predict the most relevant services that users will use in the current situation based on their habits, and provide services in Active Mode and Passive Mode. Conside...

I. The degree of electrotonic coupling between a given synapse located on a dendrite and the spike trigger zone is a major determinant of the relative influence of that synapse on neuronal firing. The degree of electrotonic coupling between a synapse and the recording site also influences the measurement of the biophysical properties of that synapse. We present theoretical justification for a p...

The accumulation of aggregated forms of the α-synuclein (αSN) is associated with the pathogenesis of Parkinson's disease (PD) and Dementia with Lewy Bodies. The loss of synapses is an important event in the pathogenesis of these diseases. Here we show that aggregated recombinant human αSN, but not βSN, triggered synapse damage in cultured neurons as measured by the loss of synaptic proteins. Pr...

During T lymphocyte (T cell) recognition of an antigen, a highly organized and specific pattern of membrane proteins forms in the junction between the T cell and the antigen-presenting cell (APC). This specialized cell-cell junction is called the immunological synapse. It is several micrometers large and forms over many minutes. A plethora of experiments are being performed to study the mechani...