Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection [1]. The syndrome is characterised by autonomic dysfunction and increased plasma levels of noradrenaline and adrenaline [2]. These catecholamines originate mainly from the activated sympathetic nervous system, but also originate from the adrenal gland, gut, and immune cells [3]. While nec...

40 Cardiac output measurement from arterial pressure waveforms presumes a defined relationship 41 between the arterial pulse pressure (PP), vascular compliance (C) and resistance (R). Cardiac 42 output estimates degrade if these assumptions are incorrect. We hypothesized that sepsis would 43 differentially alter central and peripheral vasomotor tone decoupling the usual pressure wave 44 propaga...

Thank you Ben and AmSECT for organizing this conference. And thank you all for showing up on Saturday morning. My objectives for this presentation are to review the current knowledge of time spent below critical thresholds and more specifically the relationship between low oxygen delivery and organ function following cardiopulmonary bypass (CPB). Additionally, we will investigate the time–dose ...

A 47-yr-old woman was brought to her local hospital because of nausea, vomiting, diffuse myalgias, and deterioration in mental status. She had been well until the night before, when, while dancing at a party, she had reported epigastric–retrosternal discomfort, right lumbar pain, and vomiting with an impending sense of doom. She had no history of hypertension, diabetes, or cardiovascular diseas...

Sepsis is associated with cardiovascular changes that may lead to development of tissue hypoperfusion. Early recognition of sepsis and tissue hypoperfusion is critical to implement appropriate hemodynamic support and prevent irreversible organ damage. End points for resuscitation need to be defined and invasive hemodynamic monitoring is usually required. Targets for hemodynamic optimization sho...