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The bioavailability of a generic diclofenac sodium sustained release tablet preparation (Zolterol, SR) was compared with the innovator product, Voltaren, SR. Twelve healthy adult male volunteers participated in the study, which was conducted according to a randomized, two-way crossover design with a wash out period of one week. The bioavailability of diclofenac was compared using the parameters...

DIETHYLPROPION ("Tenuate") has been shown to be useful in the treatment of refractory obesity (Seaton et al., 1961). Appetite suppression with the standard preparation is reported to last about four hours (Spielman, 1959) and the drug must be taken at least three times daily. This paper reports the use of a longacting preparation of the drug, which need be taken only once a day. It is marketed ...

Local delivery of therapeutic angiogenic agents that stimulate blood vessel formation represents a promising strategy for the treatment of peripheral vascular disease (PVD). At present, requirements for temporal and spatial parameters for localized delivery are unclear, with a variety of sustained delivery approaches being examined. Two polymer-based sustained formulations containing the 165 am...

Background: Green tea polyphenols (GTP) are known to have several health benefits. In spite of these benefits, its application as a therapeutic agent is limited due to some of its limitations such as stability, bioavailability, and biotransformation. To overcome these limitations, liposomal nanoparticles have been used as a carrier of the GTP. <spa...

[This retracts the article on p. 137 in vol. 5, PMID: 24966835.].

This manuscript reports a new type of drug-loaded core-shell nanofibers that provide tunable biphasic release of quercetin. The nanofibers were fabricated using a modified coaxial electrospinning process, in which a polyvinyl chloride (PVC)-coated concentric spinneret was employed. Poly (vinyl pyrrolidone) (PVP) and ethyl cellulose (EC) were used as the polymer matrices to form the shell and co...

The xanthan/chondroitin sulfate (X/CS) hydrogels, obtained by a crosslinking technique, were evaluated in vitro and in vivo as matrices for theophylline release. The influence of pH of simulated physiological media on the X/CS swelling behaviour at 37 ̊C was investigated. The hydrogels theophylline loading degree was evaluated by near infrared chemical imaging (NIR-CI) technique and confirmed al...

The gastrointestinal (GIT) segment wherein dietary additives, such as butyrate, are released may influence their observed efficacy. Release kinetics are influenced by pH, gastric and enteric motility, retention time in the different GIT segments and enzymes concentration. Unfortunately, none of the available in vitro poultry model mimics accurately these conditions. As a consequence, a novel in...