The purpose of this study was to investigate the effect of adding sustained-release (SR) bupropion to cognitive behavioral therapy (CBT) on smoking behavior and stability of psychiatric symptoms in patients with schizophrenia. We conducted a 3-month, double-blind, placebo-controlled trial of bupropion SR, 150 mg/day, added to a concurrent CBT program with 3-month follow-up in 19 stable outpatie...

Dopamine supersensitivity psychosis (DSP) is a type of acute exacerbation of recurrent psychosis caused by long-term treatment with antipsychotics in schizophrenic patients. Although DSP is exceedingly troublesome for clinicians, effective treatment has not yet been established. Based on clinical research and our animal study, we hypothesize that aripiprazole, an atypical antipsychotic, may red...

Law enforcement officers, and the criminal justice system more generally, encounter psychotic individuals at a high rate due to legal infractions committed consciously or resulting from symptoms of the disorder. The purpose of this study was to determine whether a broad range of biopsychosocial symptoms predicted more severe legal problems. In addition, we studied whether a biopsychosocial mode...

Here, we report psychotic symptoms together with a right cerebellopontine-angle lesion. A37-year-old female patient presented with a trigeminal Schwannoma occupying the right cerebellopontine angle. Her psychotic symptoms included auditory hallucinations and delusions of persecution. T1- and T2-weighted images on magnetic resonance imaging (MRI) revealed hyperintense and hypointense areas in th...

BACKGROUND Psychosis is rare in untreated patients with Parkinson's disease (PD) but the prevalence rises to 40% during dopaminergic treatment. So far, no systematic comparison of the psychogenic potential of different dopaminergic drugs had been performed. METHODS Eighty PD patients with psychotic episodes were compared to an age-matched control group of PD patients without psychotic episode...

BACKGROUND The aim of the TAILOR trial is to investigate the effect of closely monitored tapering/discontinuation versus maintenance therapy with antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder and with minimum 3 months' remission of psychotic symptoms. METHODS AND DESIGN Two hundred and fifty patients will be included from the psychia...

OBJECTIVE It is not clear whether the prevalence of psychosis increases with age. We studied the age-specific prevalence of psychotic symptoms in older people in Western Europe. METHODS Older people without dementia (age 65-104 years, N = 8762) from the western part of Europe in the EURODEP concerted action took part in psychiatric examinations. RESULTS In total, 2.4% of the men and 2.9% of...

OBJECTIVE Large epidemiological surveys conducted in the developed world have found rates of psychotic symptoms in the general population to be as high as 10-28%. However, there are few data available from developing countries, including African countries, on the prevalence and correlates of psychotic symptoms. This study investigates the prevalence and correlates of psychotic symptoms (ie hall...

Abstract Cannabis is the most widely used illicit drug worldwide, and it estimated that up to 30% of people who use cannabis will develop a disorder (CUD). Demand for treatment CUD increasing in almost every region world highly comorbid with mental disorders, where sustained can reduce compliance increase risk relapse. In this narrative review, we outline evidence psychosocial pharmacological s...