نتایج جستجو برای: survivin promoter

تعداد نتایج: 93691  

2016
Y de Jong J G van Oosterwijk A B Kruisselbrink I H Briaire-de Bruijn G Agrogiannis Z Baranski A H G Cleven A-M Cleton-Jansen B van de Water E H J Danen J V M G Bovée

Chondrosarcomas are malignant cartilage-forming bone tumors, which are intrinsically resistant to chemo- and radiotherapy, leaving surgical removal as the only curative treatment option. Therefore, our aim was to identify genes involved in chondrosarcoma cell survival that could serve as a target for therapy. siRNA screening for 51 apoptosis-related genes in JJ012 chondrosarcoma cells identifie...

Journal: :Journal of Experimental & Clinical Cancer Research : CR 2009
Shin-ichi Yamashita Masao Chujo Michiyo Miyawaki Keita Tokuishi Kentaro Anami Satoshi Yamamoto Katsunobu Kawahara

BACKGROUND p53AIP1 is a potential mediator of apoptosis depending on p53, which is mutated in many kinds of carcinoma. High survivin expression in non-small cell lung cancer is related with poor prognosis. To investigate the role of these genes in non-small cell lung cancer, we compared the relationship between p53AIP1 or survivin gene expression and the clinicopathological status of lung cance...

2001
Seiji Fukuda Louis M. Pelus

The inhibitor-of-apoptosis protein survivin is expressed in most cancers and leukemias and during fetal development, but not in most normal adult tissues. Survivin expression was analyzed in umbilical cord blood (UCB) and adult bone marrow CD341 cells and in the factordependent MO7e cell line; also investigated was whether survivin expression was regulated by hematopoietic growth factors. Survi...

Journal: :Blood 2002
Seiji Fukuda Richard G Foster Scott B Porter Louis M Pelus

The inhibitor of the apoptosis protein (IAP) survivin is expressed in proliferating cells such as fetal tissues and cancers. We previously reported that survivin is expressed and growth factor regulated in normal adult CD34(+) cells. Herein, we examined survivin expression in CD34(+) cells before and after cell cycle entry and demonstrate a role for survivin in cell cycle regulation and prolife...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Donal J Brennan Elton Rexhepaj Sallyann L O'Brien Elaine McSherry Darran P O'Connor Ailís Fagan Aedín C Culhane Desmond G Higgins Karin Jirstrom Robert C Millikan Goran Landberg Michael J Duffy Stephen M Hewitt William M Gallagher

PURPOSE Survivin (BIRC5) is a promising tumor biomarker. Conflicting data exist on its prognostic effect in breast cancer. These data may at least be partly due to the manual interpretation of immunohistochemical staining, especially as survivin can be located in both the nucleus and cytoplasm. Quantitative determination of survivin expression using image analysis offers the opportunity to deve...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Matthias Grube Stephanie Moritz Ellen C Obermann Katayoun Rezvani Andreas Mackensen Reinhard Andreesen Ernst Holler

PURPOSE Survivin is a member of the inhibitors of apoptosis family and is overexpressed in different types of malignancies. Cytotoxic T cells recognizing survivin epitopes can be elicited in vitro and by vaccination in patients with leukemia, breast cancer, and melanoma. We did this study to investigate whether survivin-specific CD8+ T cells occur in patients with multiple myeloma. EXPERIMENT...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Pablo E Vivas-Mejia Cristian Rodriguez-Aguayo Hee-Dong Han Mian M K Shahzad Fatma Valiyeva Mineko Shibayama Arturo Chavez-Reyes Anil K Sood Gabriel Lopez-Berestein

PURPOSE To study the role of survivin and its splice variants in taxane-resistant ovarian cancer. EXPERIMENTAL DESIGN We assessed the mRNA levels of survivin splice variants in ovarian cancer cell lines and ovarian tumor samples. siRNAs targeting survivin were designed to silence all survivin splice variants (T-siRNA) or survivin 2B (2B-siRNA) in vitro and orthotopic murine models of ovarian ...

Journal: :Cancer research 2010
Jodi A McKenzie Tong Liu Agnessa G Goodson Douglas Grossman

Survivin expression in melanoma is inversely correlated with patient survival. Transgenic mice harboring melanocyte-specific overexpression of survivin exhibit increased susceptibility to UV-induced melanoma and metastatic progression. To understand the mechanistic basis for metastatic progression, we investigated the effects of survivin on the motility of human melanocytes and melanoma cells. ...

2003
Zhiyin Song Shixin Liu He He Naser Hoti Yi Wang Shanshan Feng Mian Wu Suzanne Pfeffer

Survivin is a member of the inhibitor of apoptosis protein (IAP) family that has been implicated in both apoptosis inhibition and cell cycle control. Recently, Survivin has attracted growing attention because of its tumor-specific expression and potential applications in tumor therapy. However, its inhibitory mechanism and subcellular localization remain controversial. Here, we report a novel S...

2008
Helen Angell

The aim of this study was to test the hypothesis that diverting the cytoplasmic subcellular localization of the anti-apoptotic form of Survivin to the nucleus would sensitize cancer cells to chemotherapeutics. Apoptosis is a morphologically and biochemically distinctive form of cell death, critical in the maintenance of tissue homeostasis. Caspases are a family of cysteine proteases that have a...

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