نتایج جستجو برای: survivin antisense

تعداد نتایج: 19309  

2015
Adrian Levitsky Malin C. Erlandsson Ronald F. van Vollenhoven Maria I. Bokarewa

BACKGROUND The identification of biomarkers that predict optimal and individual choices of treatment for patients with rheumatoid arthritis gains increasing attention. The purpose of this study was to investigate if the proto-oncogene survivin might aid in treatment decisions in early rheumatoid arthritis. METHODS Serum survivin levels were measured in 302 patients who completed the Swedish p...

2017
Yanli Chang Jianjun Xu Qingyun Zhang

Survivin is a tumor marker for bladder cancer; however the role of urinary survivin levels has not been fully elucidated due to the limitations of current detection methods. Based on two survivin-specific monoclonal antibodies (McAbs) already confirmed through enzyme linked immunosorbent assays, the present study aimed to establish a microplate magnetic chemiluminescence immunoassay (CLIA) for ...

2016
JIN ZHU CHENWEN SUN LIPING WANG MING XU YACHEN ZANG YIBIN ZHOU XIAOLONG LIU WEI TAO BOXIN XUE YUXI SHAN DONGRONG YANG

Castration-resistant prostate cancer (CRPC) remains an obstacle in the current treatment provided for prostate cancer (PCa). Survivin, an apoptosis inhibitor, has been found to be involved in the progression of PCa, and is a promising candidate target for CRPC therapy. Micro (mi)RNAs are involved in the progression of PCa through the regulation of multiple genes. One of the objectives of the pr...

Journal: :Experimental cell research 2012
Md Motarab Hossain Naren L Banik Swapan K Ray

Neuroblastoma is a solid tumor that mostly occurs in children. Malignant neuroblastomas have poor prognosis because conventional chemotherapeutic agents are hardly effective. Survivin, which is highly expressed in some malignant neuroblastomas, plays a significant role in inhibiting differentiation and apoptosis and promoting cell proliferation, invasion, and angiogenesis. We examined consequen...

2017
Jung Yong Hong Kyung Ju Ryu Chaehwa Park Mineui Hong Young Hyeh Ko Won Seog Kim Seok Jin Kim

Survivin is an inhibitor of apoptosis and is upregulated by Epstein-Barr virus (EBV) latent genes. Given the frequent association of EBV with lymphoid malignancies, survivin is expected to have prognostic value in diffuse large B-cell lymphoma (DLBCL). Thus, we measured the pretreatment serum level of survivin in DLBCL patients and analyzed its association with survival outcome and EBV status, ...

2013
MAN YANG YONGQIANG LIU SHUFANG LU ZHIFEN WANG RAN WANG YOUMEI ZI JINGDONG LI

The purpose of this study was to investigate the association between an inhibitor of apoptosis (survivin) and vascular endothelial growth factor (VEGF) expression in patients with acute lymphoblastic leukemia (ALL) prior to and following chemotherapy. Reverse transcription (RT)-PCR and western blotting were employed to analyze survivin and VEGF mRNA and protein expression. Moreover, the concent...

Journal: :Cardiovascular research 2014
Paul J H Lee Dmitriy Rudenko Michael A Kuliszewski Christine Liao M Golam Kabir Kim A Connelly Howard Leong-Poi

AIMS The aim of this study was to investigate anti-apoptotic gene therapy using ultrasound-mediated plasmid delivery of survivin, an inhibitor of apoptosis protein, to prevent apoptosis and to attenuate left ventricular (LV) systolic dysfunction in a model of heart failure induced by doxorubicin. METHODS AND RESULTS Effect of survivin transduction was investigated in vitro in rat cardiomyobla...

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