نتایج جستجو برای: sumo1
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Nonsyndromic cleft lip with or without cleft palate (NSCL/P) are common birth defects with a complex etiology. Multiple interacting loci and possible environmental factors influence the risk of NSCL/P. 12 single nucleotide polymorphisms (SNPs) in 7 candidate genes were tested using an allele-specific primer extension for case-control and case-parent analyses in northeast China in 236 unrelated ...
SUMOylation is a reversible post-translational modification which has emerged as a crucial molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune responses, carcinogenesis, cell cycle progression and apoptosis. Four SUMO isoforms have been identified, which are SUMO1, SUMO2/3 and SUMO4. The small ubiquitin-like modifier (SUMO) pathway is conserved in all eukaryo...
earlier studies reported the existence of E1 and E2 enzymes within mitochondria (Magnani et al, 1991; Schwartz et al, 1992). In addition, a more recent and growing body of evidence shows that mitochondria also contain specific E3 ligases with a prominent role in the regulation of mitochondrial dynamics. In particular, Mitol/ March5—a ubiquitin E3 ligase embedded in the outer membrane— participa...
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