Background—During the interdigestive state in humans, erythromycin 40 mg induces a premature activity front that starts in the stomach, while erythromycin 200 mg induces a prolonged period of enhanced antral contractile activity. Aims—To study the involvement of a cholinergic pathway in themotor eVects of erythromycin using the muscarinic antagonist atropine and the neural 5-HT1 receptor agonis...

BACKGROUND The antimigraine drugs ergotamine and sumatriptan may cause angina-like symptoms, possibly resulting from coronary artery constriction. We compared the coronary vasoconstrictor potential of a number of current and prospective antimigraine drugs (ergotamine, dihydroergotamine, methysergide and its metabolite methylergometrine, sumatriptan, naratriptan, zolmitriptan, rizatriptan, avitr...

BACKGROUND Migraine pain relief is reported by more than 50% of patients who receive low dose (3 mg) of sumatriptan. Currently, there is no two-step autoinjector of low-dose sumatriptan available on the market for acute migraine treatment. To fulfill this need, a fully assembled, single-dose, subcutaneous autoinjector (sumatriptan 3 mg; product-code DFN-11) was developed. The device allows for ...

OBJECTIVE To determine whether acute migraine treatment outcome is different in migraine with aura compared with migraine without aura. METHODS We examined pooled outcome data for sumatriptan treatment of migraine with and without aura from the sumatriptan/naratriptan aggregate patient database. We also examined similar outcome data for inhaled dihydroergotamine (DHE) from a single, large ran...

25 Serotonin (5-HT) modulates pain and anxiety from within the midbrain periaqueductal grey (PAG). In the 26 present study, the effects of 5-HT and 5-HT1/2 subtype selective ligands on rat PAG neurons were 27 examined using whole-cell patch-clamp recordings in brain slices. In voltage clamp, 5-HT produced 28 outward and inward currents in distinct subpopulations of neurons which varied througho...

The aim of the present study was to determine whether donitriptan and sumatriptan decreased jugular venous oxygen saturation and increased carbon dioxide partial pressure in venous blood. However, previous studies conducted with these compounds cannot discriminate whether the decrease of venous oxygen saturation is dependent of cranial vasoconstrictor. In the present study, vehicle (n = 10), do...

Chan KY, Labruijere S, de Vries R, Danser AHJ, Villalón CM, MaassenVanDen Brink A. Cranioselectivity of sumatriptan revisited. J. Headache Pain, 2010 oct; 11 Suppl.1):203 Labruijere S, Chan KY, van Houten ELAF, de Vries R, Kramer P, Danser AHJ, Villalón CM, Visser JA, MaassenVanDen Brink A. The effect of DHT on vascular reactivity. J. Headache Pain, 2010 oct; 11 Suppl.1):201 Labruijere S, Chan ...

BACKGROUND Several studies support the notion that disturbances in the central serotonergic function are related to impulsive aggression. There is recent evidence from studies on 5-HT(1B) knock-out mice that this specific receptor is involved in impulsive aggressive behavior. The aim of the present study was to investigate 5-HT(1B/1D) receptor functioning in normal intelligent hospitalized chil...

Cortical hyperexcitability is thought to explain the more enhanced contingent negative variation (CNV) amplitudes and impaired CNV habituation that have been found during the interictal period in migraine without aura. These CNV characteristics have been shown to normalize to the level of healthy controls during an attack. This study aimed to replicate the interictal findings, and additionally ...