Galactic cosmic ray (GCR) measurements of the phosphorus, sulfur, argon, and calcium isotopes made by the Cosmic Ray Isotope Spectrometer (CRIS) aboard NASA’s Advanced Composition Explorer are reported over the energy range from ∼100 to ∼400 MeV/nucleon. The propagation of cosmic rays through the Galaxy and heliosphere is modeled to determine isotopic source abundance ratios P/S , S/S , Ar/Ar ,...

Quaternary sea level fluctuations have greatly affected the sediment budgets of the continental shelves. Previous studies suggested that this caused a considerable increase in the net loss of shelf sediments. Since sediment accumulation and erosion are closely tied to the formation and re-oxidation of pyrite, we use a high-resolution record of sulfur isotope ratios (S / S) of marine sulfate to ...

Sulfur isotope analysis provides a unique probe for source-specific information and certain atmospheric reactions. Globally, aerosols in urban locations exhibit significant sulfur mass-independent fractionation (i.e., S-MIF, ?33S ? 0). The origin(s) of these S-MIF anomalies remains unclear, thereby limiting the interpretation and/or application such signals. Here, we conducted dual-isotope (?33...

Models describing the evolution of the partial pressure of atmospheric oxygen over Phanerozoic time are constrained by the mass balances required between the inputs and outputs of carbon and sulfur to the oceans. This constraint has limited the applicability of proposed negative feedback mechanisms for maintaining levels of atmospheric O(2) at biologically permissable levels. Here we describe a...

The incorporation of isotopic ethylene-C1Mmino-s-triazine (TEM), Myleran, chlorambucil, and sulfur mustard into the DNA fraction of regenerating liver and of various mouse ascites lymphomas was measured. The in vivo incorporation of these alkylating agents was estimated to be of the order of 1 mole of drug per mole of DNA polymer. Results obtained by several different methods of isolation of DN...

The isotope ratio of each of the light elements preserves individual information on the origin and history of organic natural compounds. Therefore, a multi-element isotope ratio analysis is the most efficient means for the origin and authenticity assignment of food, and also for the solution of various problems in ecology, archaeology and criminology. Due to the extraordinary relative abundance...

Phanerozoic levels of atmospheric oxygen relate to the burial histories of organic carbon and pyrite sulfur. The sulfur cycle remains poorly constrained, however, leading to concomitant uncertainties in O2 budgets. Here we present experiments linking the magnitude of fractionations of the multiple sulfur isotopes to the rate of microbial sulfate reduction. The data demonstrate that such fractio...

The alkaline perhydrolysis of the nerve agent O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX) was investigated by studying the ion-molecule reactions of HOO(-) with O,S-dimethyl methylphosphonothioate in a modified linear ion-trap mass spectrometer. In addition to simple proton transfer, two other abundant product ions are observed at m/z 125 and 109 corresponding to the S-met...

Gaseous sulfide intrusion into seagrasses growing in sulfidic sediments causes little or no harm to the plant, indicating the presence of an unknown sulfide tolerance or detoxification mechanism. We assessed such mechanism in the seagrass Zostera marina in the laboratory and in the field with scanning electron microscopy coupled to energy dispersive X-ray spectroscopy, chromatographic and spect...

The study of the metabolome presents numerous challenges, first among them being the cataloging of its constituents. A step in this direction will be the development of tools to identify metabolites that share common structural features. The importance of sulfated molecules in cell-cell communication motivated us to develop a rapid two-step method for identifying these metabolites in microorgan...