Investigators searched Medline and HealthSTAR databases from January 1, 1985 through June 30, 1999 to identify articles on suboptimal prescribing in those age 65 years and older. A manual search of the reference lists from identified articles and the authors' article files, book chapters, and recent reviews was conducted to identify additional articles. The definitions for various types of subo...

BACKGROUND STARRT recently demonstrated that many patients experience suboptimal dialysis starts (defined as initiation as an inpatient and/or with a central venous catheter), even when followed by a nephrologist for >12 months (NDT 2011). However, STARRT did not identify the factors associated with suboptimal initiation of dialysis. The objectives of this study were to extend the results of ST...

An H 2 suboptimal control problem is deened and analyzed. Then an algorithm called`H 2 suboptimal state feedback gain sequence' (H 2 SOSFGS) algorithm is developed. Rather than utilizing a `perturbation method' which is numerically stii and computationally prohibitive, the H 2 SOSFGS algorithm utilizes a direct eigenvalue assignment method to come up with a sequence of H 2 suboptimal state feed...

To promote fidelity in nuclear pre-mRNA splicing, the spliceosome rejects and discards suboptimal substrates that have engaged the spliceosome. Whereas DExD/H box ATPases have been implicated in rejecting suboptimal substrates, the mechanism for discarding suboptimal substrates has remained obscure. Corroborating evidence that suboptimal, mutated lariat intermediates can be exported to the cyto...

More intensive management can improve control blood pressure (BP) in hypertensive patients. However, many would posit that treatment intensification (TI) is not beneficial in the face of suboptimal adherence. We investigated whether the effect of TI on BP varies by adherence. We enrolled 819 patients with hypertension, managed in primary care at an academically-affiliated inner-city hospital. W...

In the context of FFT-based maximum-likelihood (ML) detection of a complex sinusoid in noise, we consider the result of terminating the FFT at an intermediate stage of computation and applying the ML detection strategy to its unnnished results. We show that detection performance increases monotonically with the number of FFT stages completed , converging ultimately to that of the exact ML detec...

It is commonly appreciated that solving search problems optimally can overrun time and memory constraints. Bounded suboptimal search algorithms trade increased solution cost for reduced solving time and memory consumption. However, even suboptimal search can overrun memory on large problems. The conventional approach to this problem is to combine a weighted admissible heuristic with an optimal ...

Practical difficulties involved in implementing stabilizing model predictive control laws for nonlinear systems are well known. Stabilizing formulations of the method normally rely on the assumption that global and exact solutions of nonconvex, nonlinear optimization problems are possible in limited computational time. In this paper, we first establish conditions under which suboptimal model pr...

Recently, a new compact representation for suboptimal alignments was proposed by Naor and Brutlag (1993). The kernel of that representation is a minimal directed acyclic graph (DAG) containing all suboptimal alignments. In this paper, we propose a method that computes such a DAG in space linear to the graph size. Let F be the area of the region of the dynamic-programming matrix bounded by the s...

We study the inherent robust stability properties of nonlinear discrete-time systems controlled by suboptimal model predictive control (MPC). The unique requirement to suboptimal MPC is that it does not increase the cost function with respect to a well-defined warm start, and it is therefore implementable in general nonconvex problems for which no suboptimality margins can be enforced. Because ...