AIMS We tested the hypothesis that mutations in the human ventricular essential myosin light chain (hVLC-1) that are associated with hypertrophic cardiomyopathy (HCM) affect protein structure, binding to the IQ1 motif of cardiac myosin heavy chain (MYH) and sarcomeric sorting in neonatal cardiomyocytes. METHODS AND RESULTS We employed circular dichroism and surface plasmon resonance spectrosc...

A model for the contractility of cells is presented that accounts for the dynamic reorganization of the cytoskeleton. It is motivated by three key biochemical processes: (i) an activation signal that triggers actin polymerization and myosin phosphorylation, (ii) the tension-dependent assembly of the actin and myosin into stress fibres, and (iii) the cross-bridge cycling between the actin and th...

1. The ionic dependence of action potentials evoked in giant smooth muscle fibres isolated by enzymatic digestion from the body wall of the marine invertebrate Beroe ovata (Ctenophora) has been investigated using conventional electrophysiological techniques. 2. Differences were observed in the two fibre types studied. The resting membrane potential was —60 ± 135 mV (JV = 25) in longitudinal mus...

The necessity to utilise environmentally friendly resources has emerged due environmental management. With the demand for production of plastics and wood materials, pollution increased. Consequently, attraction in natural fibre-reinforced polymer composites (NFPCs) is rapidly emerging construction industry, mainly replace synthetic fibre composites. intensified interest associated with manufact...

The importance of natural fibres over synthetic have gained significant attention in the research area, due to their higher specific strength, stiffness, lightweight and inexpensive. Natural fibre composites used various applications are often susceptible moisture absorption critical loadings scenarios during service life such as low-velocity impact damages which is a concern for structural non...

Histology and transmission electron microscopy studies were carried out on buffalo muscles that were subjected to repeated freeze-thaw cycles at -10 and -18°C. In the first freeze thaw cycle (-10°C) structures of muscle showed slight change and closely resembled to those of normal muscle. There were frequent gaps in the half way across the fibres and some cracks in individual fibre were also no...

The physicochemical properties of plant fibres are determined by the fibre morphology and structural features of the cell wall, which is composed of three main layers that differ in chemical composition and architecture. This composition and hierarchical structure are responsible for many of the mechanical properties that are desirable for industrial applications. As interactions between the li...

white, red and superficial. In common with teleost fish, the different types are well segregated in the body. The white fibres make up the bulk of the body, the red fibres form a band along the lateral edge of the body and the single layer of superficial fibres is confined to a narrow band between the skin and the red fibres. Each fibre type has a distinct histological and biochemical profile w...