SEE PAGE 2364 T he complexities of catecholamine physiology have intrigued physicians and the public alike for centuries. Epinephrine was isolated in 1897 by John Jacob Abel (1), and in parallel in 1901 by the Japanese scientist Jokichi Takamine (2), who called it adrenaline. Quickly the positive inotropic and chronotropic effects of catecholamines were appreciated and exploited, but by the sec...

Calreticulin (CALR) is a multifaceted protein primarily involved in intracellular protein control processes. The identification of CALR mutations in essential thrombocythemia (ET) and primary myelofibrosis that are mutually exclusive with the JAK2 V617F mutation has stirred an intensive research interest about the molecular functions of CALR and its mutants in myeloproliferative neoplasms (MPNs...

Inhibitors of the molecular chaperone HSP90 have been in clinical development as anticancer agents since 1999. Recent clinical studies, including the work of Saif and colleagues in this issue of Clinical Cancer Research, demonstrate that significant progress has been made in overcoming the obstacles preventing regulatory approval.

The morphological and biochemical response of sutural fibroblasts in vitro to continuous force was examined. Cells from mouse interparietal sutures were grown and subcultured on glass slides. Titanium disks coated with collagen were allowed to attach to the cellular multilayers. Four of the glass slides were then placed at an angle of 75 degrees for a period of three days so that continuous str...

Scheduling, or planning, is widely recognized as a very important step in several domains such as high level synthesis, real-time systems, and every-day applications. Given a problem described by a number of actions and their relationships, finding a schedule, or a plan, means to find a way to perform all the actions minimizing a specific cost function. The goal of this paper is to develop, ana...