background: hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. the present study was designed to determine the role of gamma amino butyric acid b (gabab) receptor and l-arginine (l-arg) in gaba-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. methods: diabetes was induced by a single i.p. injection of strepto...

Diabetes, which causes oxidative stress-induced neuronal damage, is still one of the most important chronic health problems in world. It can cause serious cellular loss and damage throughout course disease. hypothesized that increased stress this process increases free reactive oxygen species (ROS) apoptotic markers diabetic damage. Alpha-Lipoic acid (α-LA), has a direct antioxidant effect ROS ...

Diabetes mellitus is associated with many complications including retinopathy, nephropathy, neuropathy and angiopathy. Increased cardiovascular risk is accompanied with diabetes-induced endothelial dysfunction. Pharmacological agents with endothelium-protective effects may decrease cardiovascular complications. In present study sulodexide (glycosaminoglycans composed from heparin-like and derma...

Background: Previous studies have shown the beneficial effects of Prosopis species in the treatment of diabetes in traditional medicine. This study was performed to evaluate the antihyperglycemic effects of Prosopis farcta (P.farcta) in streptozocin- induced diabetic rats. Methods: Diabetes was induced by intraperitoneal injection of streptozocin (55mg/kg...

Objective(s): Diabetes mellitus (DM) is a widespread metabolic disorder worldwide. Clinical physicians have found diabetic patients have mild to middle cognitive dysfunction and an alteration of brain monoaminergic function. This study explored the change in various patterns of behavioral models and brain monoamine function under streptozotocin (STZ)-induced type 1 diabetes.Materials and Method...

Diabetic retinopathy remains a primary source of blindness with the growing pandemic diabetes. Numerous studies have shown that early neurodegeneration caused by elevated oxidative stress may initiate microvascular damage in diabetic retina during last few decades. A variety preventive and treatment strategies using phytochemicals possess high antioxidants great promise reducing diabetes-induce...