Background: Early diagnosis of patients in the early stages of Alzheimer's, known as mild cognitive impairment, is of great importance in the treatment of this disease. If a patient can be diagnosed at this stage, it is possible to treat or delay Alzheimer's disease. Resting-state functional magnetic resonance imaging (fMRI) is very common in the process of diagnosing Alzheimer's disease. In th...

IT is always salutary and oft(en inspiring to look back onl our origins, and to a generation-which has been brought up in the Royal Victoria Hospital, one of the most modertn and best-equipped hospitals in the world, it may be of interest to learn something of what the "o0l(Royal" was like. The building still stands, but greatly altered in appearance. Those who, like myself, first approache(d i...

let $g=(v,e)$ be a connected graph. the eccentric connectivity index of $g$, $xi^{c}(g)$, is defined as $xi^{c}(g)=sum_{vin v(g)}deg(v)ec(v)$, where $deg(v)$ is the degree of a vertex $v$ and $ec(v)$ is its eccentricity. the eccentric distance sum of $g$ is defined as $xi^{d}(g)=sum_{vin v(g)}ec(v)d(v)$, where $d(v)=sum_{uin v(g)}d_{g}(u,v)$ and $d_{g}(u,v)$ is the distance between $u$ and $v$ ...

if we think of the graph as modeling a network, the vulnerability measure the resistance of the network to disruption of operation after the failure of certain stations or communication links. many graph theoretical parameters have been used to describe the vulnerability of communication networks, including connectivity, integrity, toughness, binding number and tenacity.in this paper we discuss...

Every route of a transport network approaching equilibrium can be represented by a vector of Euclidean space which length quantifies its segregation from the rest of the graph. We have empirically observed that the distribution of lengths over the edge connectivity in many transport networks exhibits scaling invariance phenomenon. We give an example of the canal network of Veneice to demonstrat...

Background—To determine if the APOE e4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTL) during successful memory encoding in young adults. Methods—Twenty-four healthy young adults, twelve carriers and twelve non-carriers of the APOE e4 allele, were scanned in a subsequent memory paradigm, using event-related functional magnetic resonance imagi...

The topic of entrepreneurship has been the subject of a considerable amount of academic interest over the last twenty years. Despite a vast amount of published work there have been very few attempts to study the entrepreneurial process. In other words, we know little of the what happens as an entrepreneur moves from idea to the objective reality of a fully functioning business. A more recent ph...

Urban models can be seen on a continuum between iconic and symbolic. Generally speaking, iconic models are physical versions of the real world at some scaled down representation, while symbolic models represent the system in terms of the way they function replacing the physical or material system by some logical and/or mathematical formulae. Traditionally iconic and symbolic models were distinc...