Biopsy specimens and tissues obtained at necropsy from two women who died after developing the Churg-Strauss syndrome were analysed to see whether granulomas in these patients contained activated eosinophils or secreted eosinophil cationic proteins, or both. Immunocytochemical studies with monoclonal antibody EG2 showed large amounts of eosinophil cationic protein and eosinophil protein-X (whic...

The Cytokine Storm Syndrome (CSS) is characterized by an overwhelming activation of immune cells observed in life-threatening disorders such as familial hemophagocytic lymphohistiocytosis (fHLH) and secondary (s) HLH/ macrophage activation syndrome (MAS) as well as during serious infection. However, it is not known if the CSS can be attributed to a single cytokine. Increased blood levels of int...

I read with interest the case report by Tuggey and Hosker where Churg-Strauss syndrome was associated with the use of montelukast in an asthmatic patient in whom there was no recent exposure to oral corticosteroid. However, it is worth noting that the patient was using a high dose of inhaled fluticasone propionate (1.5 mg/day) via a large volume spacer prior to the introduction of montelukast. ...

Shanghai, China, postulated that MVP may have been the result of structural damage and functional derangement caused by the underlying vasculitis of BD. Whereas the association of MVP and BD may be either causally related or coincidental, it is important to keep in mind that, although BD is relatively rare in the United States, MVP is very common. BD occurs most frequently in Japan and in the M...

A 57-year-old man with a history of more than 10 years of bronchial asthma and chronic sinusitis complained of double vision which developed 18 days after cardiac tamponade with eosinophil-rich fluid (eosinophils 30%). He had oculomotor nerve palsy, and a blood test revealed eosinophilia (12,700/mm(3)) and elevation of both C-reactive protein and rheumatoid factor. He was diagnosed as having Ch...

INTRODUCTION Ishikawa and Jefferson are the two most commonly used systems used for the classification of cavernous sinus syndrome (CSS). However, relative utilities of these two classification systems have not been evaluated in detail in developing countries. In this study, we compared relative utilities of these two classification schemes in the evaluation of CSS. OBJECTIVE To compare the u...

CHURG-STRAUSS SYNDROME Churg-Strauss syndrome is a rare small vessel vasculitis manifested by fever, asthma, and hypereosinophilia. This disease is also referred to as allergic angiitis and granulomatosis, • A patient’s combined genetic predisposition and regulatory mechanisms control expression of the immune response to antigens. • Negative test results for antineutrophil cytoplasmic antibodie...

A 28-year-old woman with a history of asthma and recent deep venous thrombosis presented with fever, chest pain, and peripheral eosinophilia. The patient was subsequently diagnosed with Churg-Strauss syndrome and HIV infection, representing to our knowledge only the second case of this association. Rheumatologic manifestations of HIV may precede clinical signs of infection. This is significant ...

Adjuvant medical treatment steroid therapy of polyarteritis nodosa. Specific treatments are sometimes required. 55: 146–155 renal vasculitis. Angiotensin converting enzyme inhib-10. Guillevin L, Jarrousse B, Lok C et al. Long-term followup after itors or angiotensin II-receptor blockers are effective treatment of polyarteritis nodosa and Churg–Strauss angiitis and able to control severe or mali...

The increasing rates of cesarean section are accompanied by a corresponding increase in the complications associated with operation, including scar syndrome (CSS). CSS refers to clinical presentation abnormal genital bleeding, pelvic pain, and/or infertility woman cesarean-induced isthmocele. is risk serious such as uterine rupture and preterm delivery; however, not widely known.