the human mdr1 gene encodes for a p-glycoprotein (pgp), which acts as an efflux pump that transports a large variety of substrates from the inside of cells to the outside until protection against xenobiotics. the g2677t/a polymorphism in exon 21 is associated with pgp expression and function in humans. the present study was aimed to determine the frequencies of this polymorphism in a healthy po...

A new novel test method, associated analysis, and experimental procedures are developed to investigate the toughness of the facesheet-to-core interface of a sandwich material at cryogenic temperatures. The test method is designed to simulate the failure mode associated with facesheet debonding from high levels of gas pressure in the sandwich core. The effects of specimen orientation are conside...

Deep rock engineering is in a high pre-stressed state before excavation. In this research, method to calculate the release of strain energy caused by excavation proposed. The normal stress after leads reduction specimens. influence height and width on inconsistent under vertical loading. When hole 1 mm, large, increase slow release. very small, an increasingly faster energy. This exponentially ...

A recent variational mechanics analysis of microcracking damage in cross-ply laminates of the form [(S)/90n]s, where (S) is any orthotropic sublaminate much stiffer than [90n], has been extended to account for the presence of delaminations emanating from the tips of microcracks in the [902n]T sublaminate. The new two-dimensional stress analysis is used to calculate the total strain energy, effe...

Prediction of soft tissue failure may yield a better understanding of the pathogenesis of arterial dissection and help to advance diagnostic and therapeutic strategies for treatment of this and other diseases and injuries involving the tearing of soft tissue, such as aortic dissection. In this paper, we present computational models of tear propagation in fibre-reinforced soft tissue that underg...