Early on in our training as ophthalmologists, we are taught how to diagnose amblyopia and promptly initiate its treatment. Although such information during the learning process seems to be quite valuable, evidence is lacking for some of the procedures used to treat amblyopia that have been taught to successive generations of ophthalmologists. Nobel laureates Hubel and Wiesel characterized the b...

For five anisometropic amblyopes and five normal controls, contrast sensitivities in both grating motion direction discrimination and moving grating detection were measured with the same moving sine-wave stimuli over a wide range of spatial and temporal frequencies. We found that the apparent local motion deficits in anisometropic amblyopia can be almost completely accounted for by deficits in ...

PURPOSE This study was designed to assess and compare the thicknesses of the fovea and the retinal nerve fiber layer in normal children and children with amblyopia. METHODS Optical Coherence Tomography (OCT) was performed on 26 children (52 eyes total) with unilateral amblyopia that was due to anisometropia or strabismus. OCT was also performed on 42 normal children (84 eyes), for a total of ...

Previous studies have employed different experimental approaches to enhance visual function in adults with amblyopia including perceptual learning, videogame play, and dichoptic training. Here, we evaluated the efficacy of a novel dichoptic action videogame combining all three approaches. This experimental intervention was compared to a conventional, yet unstudied method of supervised occlusion...

Amblyopia, a developmental disorder of spatial vision, is thought to result from a cascade of cortical deficits over several processing stages beginning at the primary visual cortex (V1). However, beyond V1, little is known about how cortical development limits the visual performance of amblyopic primates. We quantitatively analyzed the monocular and binocular responses of V1 and V2 neurons in ...

Here, we systematically explore the size and spacing requirements for identifying a letter among other letters. We measure acuity for flanked and unflanked letters, centrally and peripherally, in normals and amblyopes. We find that acuity, overlap masking, and crowding each demand a minimum size or spacing for readable text. Just measuring flanked and unflanked acuity is enough for our proposed...