ly large by rule, independent of specific niches and behaviors – we struggled to account for it in terms of ‘developmental constraints’ and ‘spandrels’. Now, we attempt to understand the conserved pattern of allometric scaling as a substrate for ‘evolvability’. That is, we investigate what features such a conserved plan might afford for graceful scaling and facilitated variability (that is, gen...

The workhorse of modern macroeconomics is the New Keynesian model. This model assumes that monetary policy is transmitted through the path of the shortterm nominal interest rate. Money, if it is included at all, is relegated to an inconsequential role in monetary policy analysis. The purpose of this paper is twofold. First, we summarize the literature on the existence and role of money that is ...

¿Habla español? Ba. n có nói tiếng viҲt? If you don't, then make sure you bring the interpreter into that patient's room. Not only is it likely your hospital's policy and a Joint Commission requirement, 1 but it's also good medical care. The pediatric literature over the past few decades has highlighted the importance of quality interpretation for Limited English Profi cient (LEP) patients to p...

This paper investigates whether beta can predict the expected return after controlling for the beta instability resulting from shift in the covariance structure. Such a shift is driven by idiosyncratic volatility’s clientele effect: speculative investors prefer stocks with high idiosyncratic volatility. Consequently, these stocks tend to have low future returns from overpricing, and high beta b...

Recently, I wondered if my and countless other nurses’ entire careers had been in vain. Forty plus years in clinical, education, research and culture change—and for what? What could provoke such angst? Read this new blog post from The King’s Fund (2017a) and you will find out. Chris Ham and Don Berwick may be the Lennon and McCartney of health policy and quality so when they speak, I definitely...

Do not forget that when you sneeze, the fairies are endeavouring to carry you off, and that if a sudden lameness overtakes you, it indicates that you have been trespassing on fairy ground. The great safeguards against the fairies are fire, iron, and dung, the last-mentioned because the fairies, being pure spirits, cannot bear defilement. Never take fire out of a house with a person sick within ...

—The Editors A s a nutrition professor, I am constantly asked why nutrition advice seems to change so much and why experts so often disagree. Whose information, people ask, can we trust? I’m tempted to say, “Mine, of course,” but I understand the problem. Yes, nutrition advice seems endlessly mired in scientific argument, the self-interest of food companies and compromises by government regulat...

Hodgkin's disease is one of the first cancerous diseases for which effective treatment options have been developed. While this disease still ended lethally earlier, the prognosis is very good today. This is particularly due to the radiation sensitivity of lymphoma. 80 % of the patients can be cured permanently. This article provides a comprehensive overview of the hematologic disease, the sympt...

INTRODUCTION Adult Still Disease (ASD) is a rare (incidence 1-1,6/1,000,000 in Europe) seronegative polyarthropathy diagnosed with clinical criteria, excluding other etiologies. Minocycline, a semisynthetic derivative of tetracycline, has been associated with many adverse effects. We present the case of a 18-years-old man with a high suspicion of an adverse drug reaction (ADR), that was finally...

Diagnosis of tuberculosis in children is challenging; even with advanced technologies, the diagnosis is often difficult to confirm microbiologically in part due to the paucibacillary nature of the disease. Clinical diagnosis lacks standardization, and traditional and molecular microbiologic methods lack sensitivity, particularly in children. Immunodiagnostic tests may improve sensitivity, but t...