Since 1934, when it was shown that ergosterol is not the only provitamin D occurring in nature (l), the provitamin D content of the mixed sterols from many sources has been investigated (2-6). It has been found that the sterols from many of the invertebrates contain a surprisingly large amount of provitamin D as measured spectroscopically. Windaus (3) and Bock and Wetter (4) were able to isolat...

In the preceding paper (1) we have investigated the metabolic basis for the sterol requirements of insects and have provided evidence to show that in the case of the beetle Dermestes vulpinus cholesterol biogenesis is multiply blocked. While the lack of sterol synthesis seems to be a metabolic defect common to all insects, the requirements for specific sterols vary widely among insect species. ...

STUDY OBJECTIVE To compare the efficacy and safety of plant sterols and stanols as well as policosanol in the treatment of coronary heart disease, as measured by a reduction in low-density lipoprotein cholesterol (LDL) levels. DESIGN Systematic review and meta-analysis of randomized controlled trials. PATIENTS A total of 4596 patients from 52 eligible studies. MEASUREMENTS AND MAIN RESULT...

A dietary supply of sterol is an indispensable growth requirement for all species of insects that have been studied (l-3). This requirement has been found to be satisfied in all cases by cholesterol, and in most by either cholesterol or a phytosterol, although in a given insect species growth is not always as rapid with some types of sterols as with others (4-6). Earlier reports from this labor...

The first identification of a sterol in Chlorella was by Klosty and Bergmann (5) in 1952 when they isolated ergosterol from Chlorella pyrenoidosa. More recently, Otsuka (6) identified ergosterol and a A5 sterol in Chlorella ellipsoidea. Ergosterol was the principal component of the mixture. Recent work in this laboratory has been centered about the identification of sterols from other species o...

Enhanced biliary secretion and high faecal excretion of cholesterol are associated with increased cholesterol synthesis in coeliac disease. We have further investigated cholesterol synthesis in coeliac disease by determining the concentrations of faecal steroids and cholesterol precursors in serum, with and without a gluten free diet and while taking cholestyramine. The levels of unesterified m...

The sterol fraction of Acanthamoeba (Neff) contains 60% 7-dehydrostigmasterol and 40% ergosterol. The sterols were characterized by infrared and ultraviolet spectroscopy, gas chromatography, specific reactions, and mass spectral analysis. Sterols constitute 5% of the lipids and 15% of the neutral lipids in this species.

Moderate hypercholesterolaemia still remains one of the commonest metabolic disorders in developed societies, largely due to the effect of an inappropriate diet with high intake of saturated and trans fatty acids. This form of hypercholesterolaemia is often accompanied by arterial hypertension which may increase the atherogenicity of even moderately increased concentrations of the LDL fraction....

I n 1909, Windaus published the important discovery that cholesterol, sitosterol, and P-cholestanol form sparingly soluble addition compounds with digitonin, whereas a-cholestanol and cholesterol esters do not (1). Ever since, this reaction has been a major tool of steroid chemists; it has been used in many methods for cholesterol determination and in many separations of steroids with the beta ...

Sitosterolaemia is a rare autosomal recessive lipid disorder characterized by increased absorption of plant sterols in the gut and decreased biliary excretion of sterols causing accumulation of plasma sterols, which can lead to premature atherosclerosis. Here we reported a boy presented with multiple tuberous xanthomas at 4 year sold and was diagnosed sitosterolaemia [1]. The fasting plasma tot...