Relapse of castration-resistant prostate cancer (CRPC) that occurs after androgen deprivation therapy of primary prostate cancer can be mediated by reactivation of the androgen receptor (AR). One important mechanism mediating this AR reactivation is intratumoral conversion of the weak adrenal androgens DHEA and androstenedione into the AR ligands testosterone and dihydrotestosterone. DHEA and a...

We have investigated the mechanism by which vitamin B6 acts to modulate steroid hormone-mediated gene expression. We show that the level of glucocorticoid-induced gene expression from simple promoters, containing only hormone response elements and a TATA sequence, was not affected by alterations in intracellular vitamin B6 concentration. However, modulation of hormone-induced gene expression wa...

Lymphoid interstitial pneumonia (LIP) is a poorly understood lymphoproliferative disorder that can be idiopathic or associated with different conditions. LIP is considered to be steroid responsive. However, its response is mainly unpredictable with a high mortality rate. Here we describe a rare case of idiopathic LIP that shows clinical improvement to Mycophenolate Mofetil after intolerable sid...

Hashimoto's encephalopathy is a steroid-responsive, relapsing or progressive encephalopathy associated with thyroid autoantibodies. Age at presentation varies from 10 to 78 years. In children, Hashimoto's encephalopathy is rare, and seizures, confusion and hallucinations are the most commonly described features. We report a 10-year-old girl with the diagnosis of Hashimoto's encephalopathy and r...

A number of corticosteroid responsive diseases have been shown to undergo exacerbation in the puerperium. The presentation of a woman 8 weeks after delivery with severe hypercalcaemia, a highly steroid sensitive feature of sarcoidosis, adds to the evidence that sarcoidosis can also be numbered amongst such diseases with relapse in the puerperium.

A 66-year-old Japanese male with a history of Behçet disease exhibited oral and genital ulcers, and a round deep ileocecal ulcer. He was treated with a combination of mesalazine and 20 mg/day of prednisolone (PSL), but was only partially responsive to PSL and we were not able to reduce the steroid dosage. Adalimumab was also administered. However, the ulcer was not completely responsive, and we...

Objective We report a series of children with encephalopathy associated thyroid antibodies who are refractory to steroid monotherapy. Background Steroid Responsive Encephalopathy autoimmune thyroiditis (SREAT) is rare condition, only few isolated cases reported in children. Marked clinical improvement following treatment steroids, hallmark SREAT. Design/Methods An IRB approved chart review was ...

Steroid responsive encephalopathy associated withSteroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT), (also known as Hashimoto's encephalopathy) is a rare autoimmune encephalitis associated with high antithyroid antibodies, and presents with a relapsing-remitting or monophasic course, consisting of confusion, seizures, psychosis, dementia, or stroke-like episodes. I...

A patient developed fever, bronchoconstriction, hypoxaemia, pulmonary infiltrates, and serum and bronchoalveolar lavage fluid eosinophilia on two occasions after inhaling crack cocaine. Transbronchial biopsy specimens showed normal lung parenchyma but a dense eosinophilic infiltrate within the bronchial wall. Both episodes resolved promptly after treatment with corticosteroids. Eosinophilic lun...