Brain tumor patients routinely undergo cranial radiotherapy, and while beneficial, this treatment often results in debilitating cognitive dysfunction. This serious and unresolved problem has at present, no clinical recourse, and has driven our efforts to more clearly define the consequences of different brain irradiation paradigms on specific indices of cognitive performance and on the underlyi...

Twenty-two patients undergoing CT-guided stereotaxic biopsies had intraoperative monopolar and bipolar impedance monitoring along the trajectory of the biopsy. Patterns of tissue impedance were retrospectively correlated with CT scans demonstrating decreased impedance generally corresponding to low density regions and increased impedance to the enhancing lesions.

The cerebellar nuclei are involved in several brain functions, including the modulation of motor and cognitive performance. To differentiate their participation in these functions, and to analyze their changes in neurodegenerative and other diseases as revealed by neuroimaging, stereotaxic maps are necessary. These maps reflect the complex spatial structure of cerebellar nuclei with adequate sp...

Standard stereotaxic reference systems play a key role in human brain studies. Stereotaxic coordinate systems have also been developed for experimental animals including non-human primates, dogs, and rodents. However, they are lacking for other species being relevant in experimental neuroscience including sheep. Here, we present a spatial, unbiased ovine brain template with tissue probability m...

We report the case of a woman with intracranial metastasis from an esophageal gastrointestinal stromal tumor (GIST) with the mutation site in the 3' end of exon 11. Frontal craniotomy was performed with complete resection of the mass, followed by postoperative stereotaxic radiotherapy (SRT). Intracranial metastasis from GISTs is extremely rare; we found only seven case reports in the literature.

In the present study, we have investigated the effects of silymarine on depression and the possible role of serotonergic system in these effects. The rats were anesthetized intraperitoneally with ketamine hydrochloride and placed in a Stoelting stereotaxic instrument. A stainless steel guide cannula (22-gauge) was implanted in the third ventricular region. The third ventricular region was infus...

1Department of Medical Physics, University of Patras, 26 500 Rion Patras, Greece 2Department of Physics, University of Potsdam, D-14415 Potsdam, Germany 3Institute of Medicine, Research Centre Jülich, D-52425 Jülich, Germany 4Central Electronics Laboratory, Research Centre Jülich, D-52425 Jülich, Germany 5Department of Stereotaxic and Functional Neurosurgery, University of Cologne, 50924 Cologn...