(4-Phenoxyphenylsulfonyl)methylthiirane (SB-3CT) is the selective inhibitor of matrix metalloproteinase 2 (MMP2). The inhibition mechanism of MMP2 by SB-3CT involves C-H deprotonation with concomitant opening of the three-membered heterocycle. In this study, the energetics of the deprotonation-induced ring-opening of (4-phenoxyphenylsulfinyl)methylthiirane, the sulfoxide analogue of SB-3CT, are...

Introduction Collagen is a fibrous protein comprising a right-handed, triple-helical bundle of three parallel, left-handed polyproline II-type helices. Each strand consists of approximately 300 repeats of the trimer (Xaa–Yaa–Gly), where Xaa is often (2S)proline (Pro) and Yaa is often (2S,4R)-4-hydroxyproline (Hyp) [1]. The most abundant protein in vertebrates, collagen is of fundamental importa...

A novel quinoline-substituted pyrimidine ligand forms two different coloured complexes upon reaction with Re(CO)5Br. These compounds display distinct photophysical properties that are dictated by their stereochemistry.

cancer patients are more susceptible to adverse drug-drug interactions (ddis) due to receiving multiple medications especially chemotherapy medications, hormonal agents and supportive care drugs. the aim of this study is to describe the prevalence of potential ddis and to identify risk factors for these potential interactions in hospitalized cancer patients in a developing country.a cross-secti...

the organization of gall on the ovary ofsesamum indicum l induced by the gall midge, asphondylia sesami felt, not only affects biochemical equilibrium of the host but also causes disturbed vegetative growth and reduced seed-setting. the toxicity created by the gall maker induces the re-orientation of vasculature cecidogenetic stimuli lead to excessive hypertrophy and hyperplasy forming the gall...

interference with microtubule polymerization results in cell cycle arrest leading to cell death. colchicine is a well-known microtubule polymerization inhibitor which does so by binding to a specific site on tubulin. a set of 3',4'-bis (substituted phenyl)-4'h-spiro[indene-2,5'-isoxazol]-1(3h)-one derivatives with known antiproliferative activities were evaluated for their t...

drug therapy is a complex and important process and because of the importance of drug interactions, especially in in-patients, accompanying problems and obstacles would exist as a result of concomitant use of drugs in these patients. for this purpose 3130 prescription order forms from bou-ali hospital were collected and all potential drug interactions presentwere extracted and evaluated in term...