Diffusion-weighted imaging coupled with tractography is the only method for in vivo mapping of human white-matter fascicles. Tractography takes diffusion measurements as input and produces a large collection of white-matter fascicles as output; the connectome. We introduce a method to evaluate the evidence supporting connectomes. Linear Fascicle Evaluation (LiFE) takes any connectome as input a...

This article will define how best to analyse data collected from a longitudinal follow up on contraceptive use and discontinuation, with special consideration to the needs of developing countries. Accessibility and acceptability of contraceptives at the ground level remains low and it is an overlooked area of research. The author presents a set of propositions that are closer in spirit to pract...

Standardized Field Sobriety Tests (SFSTs) are used as qualitative indicators of impairment by alcohol in individuals suspected of DUI. Stuster and Burns authored a report on this testing and presented the SFSTs as being 91% accurate in predicting Blood Alcohol Concentration (BAC) as lying at or above 0.08%. Their conclusions regarding accuracy are heavily weighted by the large number of subject...

In this work we comprehensively categorize image quality measures, extend measures defined for gray scale images to their multispectral case, and propose novel image quality measures. They are categorized into pixel difference-based, correlation-based, edge-based, spectral-based, context-based and human visual system (HVS)-based measures. Furthermore we compare these measures statistically for ...

BACKGROUND The coefficient of variation (CV) is defined as the standard deviation (sigma) of the fluorescent intensity of a population of beads or pixels expressed as a proportion or percentage of the mean (mu) intensity (CV = sigma/mu). The field of flow cytometry has used the CV of a population of bead intensities to determine if the flow cytometer is aligned correctly and performing properly...

Evaluation methodology, and particularly its statistical tests associated, plays a central role in the information retrieval domain which maintains a strong empirical tradition. In an effort to evaluate the retrieval effectiveness of a search algorithm, this paper focuses on the average precision over a set of fixed recall values. After reviewing traditional evaluation methodology through the u...

In 2010, Rolf Spiker approached one of us with a query from a client concerning advisory material in IEC 61508 on the statistical evaluation of software. We realised that there is a dearth of practical guidance for those who wish to evaluate critical software statistically. We believe statistical evaluation of software is an increasingly important assurance technique. We commence with a brief i...

We adopt a process-centric approach to computational creativity, based on a model of people’s innate ability to process analogical comparisons. A three-phase model of analogical reasoning is adapted to function as an analogy generating machine. It is supplied with two distinct knowledge-bases containing many domain descriptions, with the aim of generating novel analogies – potentially even crea...

Among the most important issues in the design of a clinical trial is the selection of the primary endpoint. Fleming et al. (1998) provided two criteria to govern its selection: the endpoint should be (i) sensitive to treatment effects, and (ii) clinically relevant. Endpoints that directly reflect how a patient feels, functions, or survives have clear clinical relevance; we refer to these as tru...