The Wistar-Furth (WF) rat is protected against chronic renal disease (CRD) following 5/6th ablation/infarction vs. the Sprague-Dawley (SD) rat, and protection was associated with preserved renal nitric oxide (NO) production. This study examined CRD induced with repeated administration of puromycin aminonucleoside (PAN). SD PAN developed nephrotic range proteinuria (>1 g/24 h), and at 15 wk seve...

Nephrotic syndrome (NS) is characterized by structural changes in the actin-rich foot processes of glomerular podocytes. We previously identified high concentrations of the small heat shock protein hsp27 within podocytes as well as increased glomerular accumulation and phosphorylation of hsp27 in puromycin aminonucleoside (PAN) -induced experimental NS. Here we analyzed murine podocytes stably ...

High Noon (1952) was a landmark artifact of American popular political culture of the high Cold War. Screenwriter Carl Foreman intended it as a commentary on Hollywood capitulation to HUAC. Director Fred Zinneman and star Gary Cooper saw it as a film about the nobility of the individual in the face of a failure of public morality. John Wayne, the film star and conservative archetype of the peri...

Polarizing discussions on political and social issues are common in mass and user-generated media. However, computer-based understanding of ideological discourse has been considered too difficult to undertake. In this paper we propose a statistical model for ideology discourse. By ideology we mean “a set of general beliefs socially shared by a group of people.” For example, Democratic and Repub...

Ideological health education of college students is very important to their healthy growth and psychological development. The main problems in the ideological health education of college students are the three aspects including delinquent students, psychological problems and fragility/incapacity. Our analytical result suggested that the three problems are very similar to the three especial diff...

Ideology and its function in digital games has received considerable scholarly interest in the field of game studies, though only more recently has criticism interested itself with the ideological implications of game mechanics in conjunction with a game's representational content. Relying on an Althusserian definition of ideology, this paper builds upon the existing methodology of procedural r...

Four studies investigated a goal regulation view of anxious uncertainty threat (Gray & McNaughton, 2000) and ideological defense. Participants (N = 444) were randomly assigned to have achievement or relationship goals implicitly primed. The implicit goal primes were followed by randomly assigned achievement or relationship threats that have reliably caused generalized, reactive approach motivat...

We estimated ideological preferences of 3.8 million Twitter users and, using a data set of nearly 150 million tweets concerning 12 political and nonpolitical issues, explored whether online communication resembles an "echo chamber" (as a result of selective exposure and ideological segregation) or a "national conversation." We observed that information was exchanged primarily among individuals ...

AORTIC (OAREC), the Pan - African organization aiming to unite African scientists in the fight against cancer on the continent, held its 2015 conference in November, in Marrakesh. It was an opportunity to evaluate the progress made, to strengthen scientific collaborations and to draw the future battle lines against cancer on the continent.

BACKGROUND We previously reported that puromycin aminonucleoside (PAN) increased adrenomedullin (AM) secretion and AM mRNA expression in podocytes, through overproduction of oxidative stress. To clarify the cytoprotective role of AM as antioxidative and antiapoptotic substance in podocytes, we investigated the effect of exogenous AM and AM antagonist on PAN-induced apoptosis in conditionally im...