Heparin is a widely used anticoagulant due to its ability to inhibit key components in the coagulation cascade such as Factor Xa and thrombin (Factor IIa). Its potential to preferentially bind to antithrombin (ATIII) results in a conformational change and activation that leads to the prevention of fibrin formation from fibrinogen and ultimately obstructs a hemostatic plug from forming. Nitric o...

Although the lability of heparin in mild acid has been studied (l-4), the conditions for thermoinactivation have not been clearly defined. Thus, experiments were designed to evaluate the loss in anticoagulant activity of heparin solutions in varying hydrogen ion concentrations over a wide range of temperatures. Samples were adjusted to pH l-4 and 7, then held 1 hr at 25, 37, 48, 58, 68, 78, 88,...

We performed a prospective, randomized, double-blind trial in 194 unselected patients to determine the safety and efficacy of low molecular weight heparin (Fragmin) compared with standard heparin as the initial treatment of acute venous thromboembolism. Ninety-eight patients received continuous intravenous heparin, and 96 patients received Fragmin for 5-10 days. Doses were adjusted to maintain ...

UNLABELLED The activated partial thromboplastin time (aPTT) and anti-Xa activity are used for monitoring unfractionated heparin (UFH) therapy in children and may not be optimal. OBJECTIVE Determine correlations of aPTT, anti-Xa and UFH dose in children. Single centre prospective cohort study in children receiving UFH. The aPTT and anti-Xa results from routine coagulation monitoring were colle...

materials and methods in a double blind randomized trial study, 100 patients undergoing elective cardiac surgery were randomized to using heparinized (n = 50) or non-heparinized (normal) saline flush (n = 50) to maintain patency of arterial catheter after operation. indwelling arterial catheters were checked daily for acceptable arterial waveform for three days as primary outcome measures. resu...

Abstract INTRODUCTION The aim of this study is to assess the effectiveness heparin inhibit development early bacteriuria as a coating for biodegradable ureteral stents. MATERIAL AND METHODS BraidStent®-H stent, whose incorporated by dip coating, was chosen study. Twenty-four swine were randomly divided into two groups: 12 animals underwent unilateral placement and fitted with standard double-j ...

Background and Aim of Study: The use of Low-molecular-weight heparin (LMWH) for hemodialysis anticoagulation has been proposed as effective and safe for hemodialysis (HD) anticoagulation as standard unfractionated heparin (UFH). The aim of our study was to assess the use of LMWH for hemodialysis anticoagulation in comparison to UFH, including hemorrhagic events and clotting of the extracorporea...

background:   objective: to investigate the association between thrombophilia and unexplained recurrent miscarriage and to evaluate the efficacy of anticoagulant treatment.   materials and methods: in this quasi experimental, we enrolled 520 women, who had a history of recurrent miscarriage. two hundred fifty two women with unexplained recurrent miscarriage were assigned to receive aspirin (80 ...

H eparin is the anticoagulant of choice when a rapid anticoagulant effect is required because its onset of action is immediate when administered by intravenous injection. Heparin is administered in low doses when used for primary prophylaxis and high doses when used therapeutically to prevent recurrent thrombosis. Its use is almost always limited to an in-hospital setting because it must be adm...

Hallgren, J., 2004. The role of heparin in the activation of mast cell tryptase. Doctor’s dissertation. ISSN 1401-6257, ISBN 91-576-6676-8 Mast cells play an important role in our immune defense against bacteria and parasites but are also key effector cells in various inflammatory diseases. They act by releasing inflammatory mediators from intracellular granules. Tryptase, one of the most abund...