Stable, non-radioactive isotopes, so long overshadowed by radionuclides, have recently become much more widely used in clinical science. This renewed interest has been stimulated by improvements both in the increased availability and diversity of stable-isotopelabelled compounds and in mass-spectrometric methods for their quantitative analysis. In addition, there is an increasing awareness of t...

Daily precipitation samples for stable isotope analysis were collected throughout 2003 at Dome Fuji Station, inland East Antarctica. Stable isotopes show significantly depleted values with a large seasonal variability, which have never been obtained. Temporal changes in δ–T relation and d–excess are consistent with those found in geographical distribution. Precipitation was obtained almost ever...

Approaching half a century of stable-isotope usage in human metabolic studies has been without documented significant adverse effect. Side-effects with acute D dosing are transitory with no demonstrated evidence of permanent deleterious action. The threshold of D toxicity has been defined in animals and is far in excess of concentrations conceivably used in human studies. The possibility that D...