Octreotide is a somatostatin analogue that is widely used for cancer therapy and tumor imaging. Its efficacy in tumors depends mainly on the expression of the somatostatin receptor type 2 (sst 2). Desensitization and down-regulation of sst 2 after agonist exposure can have important consequences for patients under ongoing octreotide therapy because it may induce temporary tumor unresponsiveness...

KEY CONCEPT Th t hibit ll b f EPOCH f t bl NASA’s Mission to “pioneer the future in space exploration, scientific discovery and aeronautics research” requires technological innovation; yet current performance is inadequate (fig 1). Although multiple innovation system have been tried (fig 2), there remains a fundamental lack of understanding of how innovation actually happens in institutions lik...

the sst decomposition method for solving system of linear equations make it possible to obtain the values of roots of the system with the specified accuracy as the limit of the sequence of some vectors. in this topic we are going to consider vectors as fuzzy vectors. we have considered a numerical example and tried to find out solution vector x in fuzzified form using method of sst decomposition.

[1] We use elemental ratio (Mg/Ca, Sr/Ca, U/Ca and Ba/Ca) and oxygen isotope data from a Porites lutea coral head collected from offshore Amédée Island, New Caledonia (22 290S, 166 280E) to assess the degree to which changes in these geochemical variables reflect variations in sea surface conditions. We have assessed the robustness of each geochemical proxy by comparing 25 years (1992–1968) of ...

Inhibitory circuitry plays an integral role in cortical network activity. The development of transgenic mouse lines targeting unique interneuron classes has significantly advanced our understanding of the functional roles of specific inhibitory circuits in neocortical sensory processing. In contrast, considerably less is known about the circuitry and function of interneuron classes in piriform ...

Sea surface temperature (SST) is an important parameter used in many applications, such as fisheries, weather forecasting as boundary condition, and monitoring of climate changes. In these applications, SST is necessary under both fine and cloudy conditions, which can be made by passive microwave radiometers in particular under cloudy condition. To measure SST by microwave radiometers, frequenc...

The clinical effectiveness of the Kampo medicine Sho-seiryu-to (SST) has recently been demonstrated in a double-blind randomized study of allergic asthma and rhinitis. We investigated the effect of SST on a type 1 allergic model in mice. Ovalbumin (OVA)-induced sneezing and the total and OVA-specific IgE levels were significantly suppressed with SST at 1.0 g/kg, but that of OVA-specific IgG(2a)...

Baratta, Michael V., Tyra Lamp, and Melanie K. Tallent. Somatostatin depresses long-term potentiation and Ca signaling in mouse dentate gyrus. J Neurophysiol 88: 3078–3086, 2002; 10.1152/jn.00398.2002. The selective loss of somatostatin (SST)-containing interneurons from the hilus of the dentate gyrus is a hallmark of epileptic hippocampus. The functional consequence of this loss, including its...

n-phthaloyl gaba was administrated daily (50 mg/kg body weight-i.p) to wistar rats for 21 days and circadian rhythms of thiobarbituric acid reactive substances (tbars) and antioxidants such as reduced glutathione (gsh), catalase (cat) and superoxide dismutase (sod) were studied under constant light (ll) conditions. delayed acrophase of tbars and advanced acrophase of antioxidants (gsh, cat and ...