OBJECTIVE To evaluate quality-of-life (QOL) aspects of an organ preservation intra-arterial chemotherapy and concomitant radiation protocol, RADPLAT. DESIGN Nonrandomized phase 2B feasibility trial. PATIENTS Fifty consecutive patients with inoperable stage IV head and neck cancer. INTERVENTION Supradose selective intra-arterial cisplatin and concomitant standard radiation (RADPLAT). MEA...

While the addition of cetuximab to radiotherapy improves clinical outcomes in locoregionally advanced head and neck squamous cell cancers, there are a small number of reports of severe radiation dermatitis occurring with this therapeutic combination. We present the case of a 69 year old male who developed severe radiation dermatitis following treatment with cetuximab and radiotherapy for a loco...

CT: computed tomography HNCSCC: head and neck cutaneous squamous cell carcinoma IMRT: intensity-modulated radiation therapy MMS: Mohs micrographic surgery PNI: perineural invasion RT: radiation therapy SCC: squamous cell carcinoma INTRODUCTION Head and neck cutaneous squamous cell carcinoma (HNCSCC) is a growing problem in the immunosuppressed population, and the behavior of these cancers can b...

Squamous cell carcinoma of the head and neck is one of the most common cancer types worldwide. It initiates on the epithelial lining of the upper aerodigestive tract, at most instances as a consequence of tobacco and alcohol consumption. Treatment options based on conventional therapies or targeted therapies under development have limited efficacy due to multiple genetic alterations typically f...

OBJECTIVE To determine if the development of hypothyroidism has an effect on the outcome of advanced-stage head and neck squamous cell carcinoma. DESIGN Retrospective database analysis. SETTING Tertiary care center. PATIENTS The study population comprised 155 patients with advanced-stage head and neck squamous cell carcinoma. INTERVENTIONS Patients underwent radiation therapy alone or i...

AIM We evaluated the prognostic value of vasohibin-1 (VASH1) expression in head and neck squamous cell carcinoma. MATERIALS AND METHODS Immunohistochemistry for VASH1 and cluster of differentiation 34 (CD34) was performed on 61 head and neck squamous cell carcinoma specimens. The association between VASH1 expression in the tumour and clinical outcomes was analyzed statistically. RESULTS VAS...

BACKGROUND The immune system plays an important role in tumour immune surveillance. Head and neck squamous cell carcinoma patients are often immune compromised. OBJECTIVE To chart the baseline levels of T-cell subpopulation frequencies in patients with cancer prior to treatment. SUBJECTS AND METHODS Blood samples of patients were taken at the time of diagnosis, analysed with flowcytometry a...

Although much has been characterized about squamous cell carcinoma of the lower female reproductive tract, there is limited knowledge and experience with cases demonstrating squamous cell carcinoma with sarcomatoid features. Sarcomatoid squamous cell carcinoma (SSCC) is mainly found in the upper aerodigestive tract with the larynx being the most common site in the head and neck region. (Otay et...

We analyzed allelic loss at the p53 gene (17p13) and at chromosome region 9p21 in 35 primary head and neck squamous cell carcinomas. Loss of heterozygosity (LOH) at p53 and 9p21 was found in 50 and 75% of informative cases, respectively. LOH at the p53 gene did not increase significantly with tumor stage, but was more frequent in moderately and poorly differentiated tumors than in well-differen...

Guideline Citation (Vancouver Style): Head and Neck Cancer Disease Site Group. The role of amifostine as a radioprotectant in the management of patients with squamous cell head and neck cancer.