The discovery and analysis of network patterns are central to the scientific enterprise. In the present work, we developed and evaluated a new approach that learns the building blocks of graphs that can be used to understand and generate new realistic graphs. Our key insight is that a graph’s clique tree encodes robust and precise information. We show that a Hyperedge Replacement Grammar (HRG) ...

Despite the fact that the epidermal growth factor (EGF) family member ERBB3 (HER3) is deregulated in many cancers, the list of ERBB3-interacting partners remains limited. Here, we report that the Apaf-1-interacting protein (APIP) stimulates heregulin-β1 (HRG-β1)/ERBB3-driven cell proliferation and tumorigenesis. APIP levels are frequently increased in human gastric cancers and gastric cancer-de...

We study the dynamical fluctuations of various particle yield ratios at different incident energies. Assuming that the particle production yields in the hydronic final state are due to equilibrium chemical processes (γ = 1), the experimental results available so far are compared with the hadron resonance gas model (HRG) taking into account the limited momentum acceptance in heavy-ion collisions...

We investigate extensions of the Hadron Resonance Gas (HRG) Model beyond ideal case by incorporating both attractive and repulsive interactions into model. When considering additional states exceeding those measured with high confidence Particle Data Group, corrections to overall pressure in HRG model are imposed. On other hand, we also apply excluded-volume corrections, which ensure there is n...

Epidermal growth factor receptor (EGFR) and receptor tyrosine-protein kinase 3 (ErbB3) are two well-established targets in cancer therapy. There is significant crosstalk among these two receptors and others. To block signaling from both EGFR and ErbB3, we generated anti-EGFR and anti-ErbB3 DVD-Ig proteins. Two DVD-Ig proteins maintained the functions of the combination of the two parental antib...

Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers. To help understand ErbB signaling quantitatively, in this work we combine traditional experiments with computational modeling, building a model that describes how stimulation of all four ErbB receptors with epidermal growth factor (EGF) and heregulin (HRG) leads to activation of two critical downstream...

This study is aimed at demonstrating the feasibility of the large scale LAI inversion algorithms using red and near infrared reflectance obtained from high resolution satellite imagery. Radiances in digital counts were obtained in 10m resolution acquired on cloud free day of August 23, 2007, by the SPOT 5 high resolution geometric (HRG) instrument onmostly temperatehardwood forest located in th...

A general framework for testing the quality of the segmentation of a multi-spectral satellite image is proposed. The method is based on the production of synthetic images with the spectral characteristics of the image pixels extracted from a signature multi-spectral image. The knowledge of the exact location of objects in the synthetic image provides a reference segmentation, which allows for a...

The Okavango delta in northwestern Botswana is an extremely complex and dynamic wetland ecosystem. The spatial information on diverse wetland features of the delta is needed for hydrological modeling and water resources management. Due to large size and inaccessibility of the delta, satellite images provide the only viable means to reliably map and measure these features. For better identificat...