PURPOSE Cancer-specific p53 mutational spectra have been identified. Data from murine models and human BRCA1-related hereditary breast cancers suggest that both unique and specific BRCA1-associated p53 mutations may be found in BRCA1-related ovarian cancers. EXPERIMENTAL DESIGN The p53 mutational spectrum from ovarian cancers containing either somatic or germ-line BRCA1 mutations was compared...

UNLABELLED Transforming growth factor beta (TGFβ) proteins are multitasking cytokines, in which high levels at tumor sites generally correlate with poor prognosis in human patients with cancer. Previously, it was reported that TGFβ downregulates the expression of ataxia telangiectasia-mutated (ATM) and mutS homolog 2 (MSH2) in breast cancer cells through an miRNA-mediated mechanism. In this stu...

Mutation in p53 (TP53) remains one of the most commonly described genetic events in human neoplasia. The occurrence of mutations is somewhat less common in sporadic breast carcinomas than in other cancers, with an overall frequency of about 20%. There is, however, evidence that p53 is mutated at a significantly higher frequency in breast carcinomas arising in carriers of germ-line BRCA1 and BRC...

background: ccl22/mdc is a cc chemokine with a critical role in regulation of the immune balance in physiological condition. ccl22/ccr-4 ligation has been documented to participate in the migration of regulatory t (treg) cells and th2 lymphocytes to the site of breast tumors; circumstances that are known to be associated with poor prognosis. objective: to investigate the association of a single...

breast carcinoma is the major cause of cancer-related death in women. the incidence of this carcinoma is rising and there are many attempts to decrease this problem. the aim of this study was detection of full-length cytokeratin 19 (ck19) mrna, in peripheral blood and tissue of breast cancer patients in early stage of cancer. in this study, rt-pcr (reverse transcriptase-polymerase chain reactio...

background: preoperative determination of the extent of viable residual tumor is an important issue after neoadjuvant treatment. on the other hand, retrospective data suggest that breast-conserving surgery is feasible up to stage iiia breast cancer without preoperative therapy. methods: we retrospectively analyzed 164 patients who underwent breastconserving surgery followed by adjuvant chemothe...

the molecular basis of metastatic potential of human breast carcinoma cells can be useful information to determine the practical implications in the diagnosis, determining prognosis and treatment of breast cancer. the aim of this study was to identify predictors of aggressive biological behavior and metastatic potential in breast carcinoma among a number of intrinsic biomarkers of tumor cells. ...