flutamide is a non-steroidal antiandrogen commonly used in the treatment of prostate cancer. severe hepatotoxicity occurs in few patients, yet may be fatal. to date, none of the reported cases of flutamide hepatotoxicity has demonstrated thrombocytopenia and chronic liver disease. we report the case of a 55-year-old male with prostatic adenocarcinoma who developed liver failure after six months...

Intravenous injection of complete Freund's adjuvant (CFA) in rats has been proposed as an experimental model for pulmonary sarcoidosis, but only some animals develop granulomas. Because the detection of the presence of granulomas and evaluation of the extent of the reaction has required histological evaluation, this model has been of limited use in following the evolution of the granulomatous p...

A 39 year old man presents with a swelling in his neck that has been progressively enlarging over the last few months. 1. What clinical tests would you perform to assess him? 2. The swelling moves upwards when the tongue is protruded. What is the likely cause, and how common is this condition? 3. Describe the embryological origin of the thyroid and its significance in this case. A representativ...

We report a case of 50-year-old man who was presented with recurrent episodes of left sided hemiparesis. CT scan and MRI brain revealed a large intraventricular fatty lesion. Histopathological examination showed a picture of angiolipoma.

Somatostatinomas are extremely rare endocrine tumors, and those with diameters above 2 cm are reported to increase the risk of metastasis significantly. We report a case of a large functional somatostatinoma in the pancreatic tail without metastases. A 46-year-old woman with a history of recurrent mild upper abdominal pain and diarrhea for 10 months was admitted to our hospital. Multiple-phase ...

BACKGROUND The sample size required to power a study to a nominal level in a paired comparative diagnostic accuracy study, i.e. studies in which the diagnostic accuracy of two testing procedures is compared relative to a gold standard, depends on the conditional dependence between the two tests - the lower the dependence the greater the sample size required. A priori, we usually do not know the...

Objective: The purpose of this study was to asses the accuracy of criteria in distinguishing distal urinary stones from phleboliths defined in the literature with thin-slice unenhanced helical computed tomography (CT). Materials and Methods: Between October 2004 and April 2005, we performed 3 cm length thin-slice (2 mm section thickness, pitch:1) helical CT on 31 patients with urinary stones an...

Fracture characteristics—such as orientation, type, fluid storage capability, and permeability—are complex yet essential information for understanding fractured reservoirs. Fractures are often perceived as permeable pathways, although many fractures partially or completely inhibit permeability within a reservoir. For example, opening-mode fractures (joints) may be partially or entirely sealed h...