نتایج جستجو برای: spink1
تعداد نتایج: 252 فیلتر نتایج به سال:
Abstract Purpose of review Premature intracellular activation pancreatic zymogens leads to the initiation pancreatitis, which in up 25% chronic tissue destruction, exocrine and endocrine organ failure, a moderate increased risk cancer development. Whereas many cases, trigger damage is identified, diagnostic workup significant number patients does not reveal underlying etiology inflammation. In ...
A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer.
Although prostate-specific antigen (PSA) serum level is currently the standard of care for prostate cancer screening in the United States, it lacks ideal specificity and additional biomarkers are needed to supplement or potentially replace serum PSA testing. Emerging evidence suggests that monitoring the noncoding RNA transcript PCA3 in urine may be useful in detecting prostate cancer in patien...
The quality of tissue samples and extracted mRNA is a major source of variability in tumor transcriptome analysis using genome-wide expression microarrays. During and immediately after surgical tumor resection, tissues are exposed to metabolic, biochemical and physical stresses characterized as "warm ischemia". Current practice advocates cryopreservation of biosamples within 30 minutes of resec...
Prostate cancer is the third most common cause of male cancer death in developed countries, and one of the most comprehensively characterized human cancers. Roughly 60% of prostate cancers harbor gene fusions that juxtapose ETS-family transcription factors with androgen regulated promoters. A second subtype, characterized by SPINK1 overexpression, accounts for 15% of prostate cancers. Here we r...
OBJECTIVE To detect mutations of trypsinogen gene (PRSS1) in patients with autoimmune pancreatitis (AIP) and to determine the underlying pathogenesis. METHODS DNA sequencing was used to detect full-length of PRSS1, cystic fibrosis transmembrane conductance regulator (CFTR), and pancreatic secretory trypsin inhibitor (SPINK1) genes mutations in an AIP family and a sporadic case and 520 normal ...
T he cardinal manifestations of chronic pancreatitis are re current or persistent abdominal pain that lasts for months to years, accompanied by diabetes, steatorrhea, and pancreatic calculi. Morphologically, the disease is characterized by destruction and loss of exocrine parenchyma that may be focal, segmental, or diffuse, as well as by fi brosis of the pancreas (Fig. 194-1). These changes may...
BACKGROUND We have previously shown that the expression of CBX7 is drastically decreased in several human carcinomas and that its expression progressively decreases with the appearance of a highly malignant phenotype. The aim of our study has been to investigate the mechanism by which the loss of CBX7 expression may contribute to the emergence of a more malignant phenotype. METHODS We analyze...
BACKGROUND The associations of ERG overexpression with clinical behavior and molecular pathways of prostate cancer are incompletely known. We assessed the association of ERG expression with AR, PTEN, SPINK1, Ki-67, and EZH2 expression levels, deletion, and mutations of chromosomal region 3p14 and TP53, and clinicopathologic variables. METHODS The material consisted of 326 prostatectomies, 166...
Hereditary pancreatitis (HP) is a rare cause of acute, recurrent acute, and chronic pancreatitis. It may present similarly to other causes of acute and chronic pancreatitis, and often there has been a protracted evaluation prior to the diagnosis of HP. Since it was first described in 1952, multiple genetic defects that affect the action of digestive enzymes in the pancreas have been implicated....
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