Mitotic spindle position defines the cell-cleavage site during cytokinesis. However, the mechanisms that control spindle positioning to generate equal-sized daughter cells remain poorly understood. Here, we demonstrate that two mechanisms act coordinately to center the spindle during anaphase in symmetrically dividing human cells. First, the spindle is positioned directly by the microtubule-bas...

Dynein mediates spindle positioning in budding yeast by pulling on astral microtubules (MTs) from the cell cortex. The MT-associated protein She1 regulates dynein activity along astral MTs and directs spindle movements toward the bud cell. In addition to localizing to astral MTs, She1 also targets to the spindle, but its role on the spindle remains unknown. Using function-separating alleles, li...

Hepatic perivascular epithelioid cell neoplasm (PEComa) is a rare type of neoplasm derived from mesenchymal tumors that is often misdiagnosed as hepatocellular carcinoma (HCC), hepatic hemangioma or other liver malignancies. The clinical and histological characteristics of PEComa have yet to be fully documented. To optimize the diagnosis and treatment of the disease, a retrospective analysis wa...

These are notes from a talk in the Arithmetic Geometry Learning Seminar on Drinfeld modules during the fall of 2017. In this talk, we discuss the uniformization of the Drinfeld modular curves (of fixed rank, with level structure), following [Dri74, §6]. In addition, we introduce the relevant rigid-analytic background. The exposition draws heavily on [DH87, Gek86]. 1. Uniformization of Complex M...

The activity of gap junction channels between cultured and clustered carotid body glomus cells of the rat was studied with dual voltage clamping during normoxia (PO(2) 300 Torr) and hypoxia induced by sodium dithionite (Na(2)S(2)O(4)) or 100% N(2). Na(2)S(2)O(4) reduced the saline PO(2) to approximately 10 Torr, whereas 100% N(2) reduced ambient O(2) to approximately 60 Torr. The following obse...

intra-tumoral bleeding, rupture and thrombosis are common complications of hemangioma but spontaneous and self limited rupture and fever is a very rare presentation of hemangioma. this report is about a 38-year-old woman with sever abdominal pain and high fever came for evaluation. in us she had a liver mass of about 15 cm in left lobe with possibility of being hemangioma and, ct scan and mri c...

Background: Effect of different doses of cysteamine on rate of in vitro maturation (IVM), in vitro fertilization (IVF) and glutathione (GSH) level was studied. Metaphase II (MII) spindle area was analyzed for quantification of shape and size of oocytes. Methods: Female mice were primed with 5 IU of pregnant mare’s stimulating gonadotrophin. Germinal vesicle (GV) oocytes were retrieved 48 hrs la...

background: effect of different doses of cysteamine on rate of in vitro maturation (ivm ) , in vitro fertilization (ivf ) and glutathione (gsh ) level was studied. metaphase ii (mii) spindle area was analyzed for quantification of shape and size of oocytes.   methods: female mice were primed with 5 iu of pregnant mare’s stimulating gonadotrophin . germinal vesicle (gv ) oocytes were retrieved 4...

Primary spindle cell sarcoma in the heart is a very uncommon disease. Although primary atrial or pulmonary vein spindle cell sarcomas have been sporadically reported, pericardial spindle cell sarcoma is rarely seen in currently available data. The commentary here is on a primary pericardial spindle cell sarcoma that was preliminarily misjudged to be left main coronary artery disease.

Primary thyroid spindle cell tumors or spindle cell component in the thyroid tumors are very rare. The spindle tumor cells were positive for thyroid papillary carcinoma markers. So these tumors were diagnosed as spindle cell variant of papillary thyroid carcinoma (PTC). To further delineate clinico-pathological features of primary thyroid spindle cell tumors and discuss differential diagnosis, ...