BACKGROUND Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord injury...

Purpose. Inflammation and apoptosis after spinal cord contusion (SCC) are important causes of irreversible injury. Interleukin-1? (IL-1?) is a key inflammatory factor that promotes the aggravation contusion. However, specific role regulatory mechanism IL-1? in still unclear. Therefore, this study applied bioinformatics to analyze mine potential gene targets interlinked with IL-1?, animal experi...

The present study aimed to explore the therapeutic effects of cyclosporin A (CsA) on spinal cord injury (SCI) in rats with hyperglycemia and to identify a novel potential method to treat SCI in the presence of hyperglycemia. Female Sprague‑Dawley (SD) rats were randomly allocated into four groups: Sham, SCI, SCI+hyperglycemia and SCI+hyperglycemia+CsA groups. Streptozotocin‑induced hyperglycemi...

HSP70 and heme oxygenase-1 (HO-1) are thought to be markers of cell injury and oxidative stress, respectively. We have immunolocalized these proteins in the spinal cord at 1-14 days after contusion. HSP70 and HO-1 were co-induced in glia and macrophages within the injured segment at all time points. This co-induction may reflect complementary functions that serve to protect these cells as they ...

objective: currently, cellular transplantation for spinal cord injuries (sci) is the subject of numerous preclinical studies. among the many cell types in the adult brain, there is a unique subpopulation of neural stem cells (nsc) that can self-renew and differentiate into neurons. the study aims, therefore, to explore the efficacy of adult monkey nsc (mnsc) in a primate sci model. materials an...

OBJECT The results of olfactory ensheathing cell (OEC) transplantation have raised great expectations as a potential treatment for spinal cord injury (SCI). Its capacity to promote functional neural repair, however, remains unclear. The authors studied axonal growth and locomotor recovery after C-7 contusion injury and OEC transplantation in adult rats. METHODS Twenty-four male Wistar rats un...

Objective: Assessment of functional recovery of neural stem cells (NSCs) and (-)-deprenyl, in a contusive spinal cord injury model in rats. Materials and Methods: A total of 24 female Sprague Dawley rats were randomly, but equally (n=6), allocated into the following groups: control, sham, NSC graft and NSC graft + (-)-deprenyl. All animals were laminectomized at the T13 level. Contusion was per...