Purpose The purpose of this study was to evaluate mechanisms controlling secretory IgA (SIgA) production, thereby ensuring maintenance of ocular surface health. Methods To determine whether the presence of specific gut commensal species regulates SIgA levels and IgA transcripts in the eye-associated lymphoid tissues (EALT), specific-pathogen-free (SPF) Swiss Webster (SW) mice were treated wit...

The aim of this study was to assess the cellular miRNA expression behaviour in testes with spermatogenic failure (SpF). We performed a high-throughput screen of 623 mature miRNAs by a quantitative RT-qPCR-based approach in histologically well-defined testicular samples with spermatogenic disruption at different germ-cell stages, which revealed altered patterns of miRNA expression. We focussed o...

The life span of intestinal epithelial cells (IECs) is short (3-5 days), and its regulation is thought to be important for homeostasis of the intestinal epithelium. We have now investigated the role of commensal bacteria in regulation of IEC turnover in the small intestine. The proliferative activity of IECs in intestinal crypts as well as the migration of these cells along the crypt-villus axi...

Outlier detection is a data analysis method and has been used to detect and remove anomalous observations from data. In this paper, we firstly introduced some current mainstream outlier detection methodologies, i.e. statistical-based, distance-based, and density-based. Especially, we analyzed distance-based approach and reviewed several kinds of peculiarity factors in detail. Then, we introduce...

Kulit buah naga merah merupakan salah satu limbah yang masih sangat jarang dimanfaatkan padahal kulit juga mengandung senyawa antioksidan cukup tinggi, mampu melawan oksidasi dalam tubuh, keunggulan dari sebagai disebabkan karena kaya akan polifenol. Minyak zaitun dapat digunakan emolien sifatnya mempertahankan kelembapan, kelenturan, serta kehalusan pada kulit. Tujuan penelitian ini yaitu untu...

Purpose: To evaluate the feasibility of a simplified method based on diffusion-weighted imaging (DWI) acquired with three b-values to measure tissue perfusion linked to microcirculation, to validate it against from perfusion-related parameters derived from intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging, and to investigate its utility to d...

This paper considers a formula for Weil’s Generalized Exponential Sums which depends entirely upon the singularities modulo π, similar to the purpose of the Stationary Phase Formula (SPF) for Igusa Local Zeta Functions (ILZF). Unlike the formula discussed in this paper, the SPF for ILZF also requires one to examine the points where the function evaulates to zero modulo π; this paper shows where...