Background: Chronic ethanol abuse causes reproductive organ failure and infertility in both humans and laboratory animals. Since sperm has a critical role in reproductive function, the objective of this unique study was to evaluate the effects of different doses of ethanol on sperm parameters, chromatin structure and apoptosis in adult mice. Materials and Methods: A total of 36 adult male mice ...

Excess reactive oxygen species (ROS) beyond the scavenging capacity of antioxidants leads to DNA damage and oxidation of lipoprotein components at the cellular and subcellular level. The oxidative stress (OS) adversely affects sperm function by altering membrane fluidity, permeability and impairs sperm functional competence. In the present study, the OS status in seminal plasma and blood serum ...

Hepatocyte growth factor (HGF) is a structurally unique growth factor with potent motogenic (motility inducing) effects. Studies in the murine male genital tract have suggested important associations between HGF and the acquisition of sperm motility during epididymal maturation. The aim of this study was, therefore, to determine the concentration of HGF in human semen and assess its correlation...

Activities of total lactate dehydrogenase, which plays an important role in providing energy for cell metabolism, lactate dehydrogenase-X, an isoenzyme of lactate dehydrogenase supposed to be specific for germinal epithelium activity, diluted semen absorbance and some other properties have been measured in 51 seminal plasma samples. Aiming to study its clinical use as a marker of seminiferous e...

Purpose: This study sought (i) to investigate the relationship between Postwash total motile sperm count and Postwash percentage motile sperm in predicting successful intrauterine insemination and (ii) to determine the minimal Postwash total motile sperm count required to achieve pregnancy with intrauterine insemination. Methods: Five hundred four women, who underwent 1636 intrauterine insemina...

Background: Since sperm parameters have a critical role in reproductive function, the objective of this study was to evaluate the effects of concomitant ethanol and saccharin consumption on sperm parameters in adult mice. Chronic ethanol consumption suppresses male reproductive function and sexual behavior in laboratory animals and humans. Furthermore, alcohol abuse by males has been correlated...

Background: Oligoasthenospermia (OAS) is a condition characterized by low sperm count associated with low sperm motility. Medical treatment is not known in allopathic system for treatment of oligoasthenospermia. Homeopathic medicine is effective in more than 95% patients. Oxidative stress and decreased antioxidant levels have been projected as a potential factors involved in the pathophysiology...

Background: Although chemotherapy drugs used in treatment of cancer such as lukemia, prostate and ovary cancer and oligospermia is important contraceptive of this drugs therefore this drugs are author of infertility or low fertility in specimen. In the other hand, the studies show that melatonin is secreted from pineal gland has a direct efficacy on the gonads. The aim of this study was to inve...

Background: Diabetes mellitus (DM), primary or idiopathic, is a chronic disorder of the carbohydrate, lipid and protein metabolism, characterized through hyperglycemia and glycosuria. DM can involve male reproductive function at many levels. Vitamin C ( ascorbic acid) is one of necessary elements in human and mammalian diet that is very important in fertility. Vitamin C prevent from gamets dama...