UNLABELLED Interaction of prion protein and amyloid-b oligomers has been demonstrated recently. Homozygosity at prion protein gene (PRNP) codon 129 is associated with higher risk for Creutzfeldt-Jakob disease. This polymorphism has been addressed as a possible risk factor in Alzheimer disease (AD). OBJECTIVE To describe the association between codon 129 polymorphisms and AD. METHODS We inve...

  Friction-stir welding process is a novel method of solid state welding, which produces heat due to friction between the pin, the shoulder and the workpiece. This heat causes a paste area. Shoulder pressure and pin spin cause edges integration and lead to welding. In this study, firstly, the feasibility of welding of steel sheet (EN10130) with a thickness of 1.5mm has been tested by 58 experim...

In the present study, the effect of material and process parameters on the morphological and hardness properties of friction stir process (FSP) acrylonitrile butadiene styrene (ABS) were investigated. For this purpose, firstly ABS polymeric sheets were injection molded. Then a slot with predetermined depth and width was created on sheets using a horizontal milling machine. Nano type (nanoclay, ...

MicroRNAs (miRNAs) are a class of small, well-conserved, non-coding RNAs that are increasingly identified as diagnostic and prognostic biomarkers in a number of cancers. Deregulated miR‑129 is closely associated with tumorigenesis and cancer progression. However, the potential role of miR‑129 in prostate cancer remains largely elusive. The present study investigated the role of miR‑129 as a pro...

In certain specific pathogen-free colonies, mice, upon aging, produce autoantibodies (RF) specific for the Fc portion of their IgG. In our colony, 129/Sv mice (H-2bvl; Igh-1a) have 10-20 times higher RF levels than C5BL/6 (h-2b; Igh-1b). In addition, the 129 have mainly IgA anti-IgG2a, and the B6 have mainly IgM anti-IgGl. We analyzed the genetic factors that control these differences. The high...

friction-stir welding process is a novel method of solid state welding, which produces heat due to friction between the pin, the shoulder and the workpiece. this heat causes a paste area. shoulder pressure and pin spin cause edges integration and lead to welding. in this study, firstly, the feasibility of welding of steel sheet (en10130) with a thickness of 1.5mm has been tested by 58 experimen...

We have selectively synthesized a number of peptides encompassing the region of helix 3 of growth hormone (GH). These peptides and native human (h) GH have been evaluated for mitogenic and receptor activities in 3T3-F442A preadipocytes. In this system, wild type hGH is anti-mitogenic. In contrast, hGH 108-129 stimulated DNA synthesis while other GH-derived peptides were ineffective. hGH (L) 108...

This paper includes modeling and simulation of 180 MW units of pumped storage power plant with Variable speed machines. In this method, voltage source inverters are used instead of traditional cyclo-converters. This paper aims to control the voltage source inverters and maintain DC voltage at a constant value. AC/ DC/ AC converter is used in system configuration structure in order to control an...