Flexible Application Specific Instruction set Processors (ASIP) are starting to replace monolithic ASICs in a vide variety of fields. However the design of an ASIP is today a substantial design effort. This paper discusses NoGAP (Novel Generator for ASIP) a tool for ASIP designs utilizing hardware multiplexed data paths. One of the main advantages of NoGAP compared to other ADL tools is that it...

We are interested in determining whether researchers and practitioners of the Domain-Specific Software Development (DSSD) community mean the same when they refer to core terms commonly used as part of the area’s nomenclature. In this position paper we report on an initial exercise we began at the 2006 OOPSLA Workshop on Domain-Specific Modeling which consisted of identifying these core terms, a...

Statistical studies of N-glycosylated proteins have indicated that the frequency of nonglycosylated Asn-Xaa-(Thr/Ser) sequons increases toward the C terminus (Gavel, Y., and von Heijne, G. (1990) Protein Eng. 3, 433-442). Using in vitro transcription/translation of a truncated model protein in the presence of dog pancreas microsomes, we find that glycosylation efficiency of Asn-Xaa-Thr sequons ...

[This corrects the article on p. 144 in vol. 6, PMID: 25798132.].

An important obstacle to the wide-spread adoption of modeldriven development approaches in industry is the lack of proper debugging facilities. Software debugging support is provided by a combination of language and Integrated Development Environment (IDE) features which enable the monitoring and altering of a running program’s state. In Domain-Specific Modelling (DSM), debugging activities hav...

Generic speech recognition systems typically use language models that are trained to cope with a broad variety of input. However, many recognition applications are more constrained, often to a specific topic or domain. In cases such as these, a knowledge of the particular topic can be used to advantage. This report describes the development of a number of techniques for augmenting domain-specif...

The crystal structure of yeast tRNAAsp enables visualization of an anticodon-anticodon interaction at the molecular level. Except for differences in the base stacking and twist, the overall conformation of the anticodon loop is quite similar to that of yeast tRNAPhe. The anticodon nucleotide triplets, GUC, of two symmetrically related molecules form a minihelix of the RNA type 11. The modified ...

The Unified Modeling Language (UML) has become a popular implementation vehicle for domain-specific modeling languages (DSMLs). A UML-based DSML is typically defined by multiple specification artifacts, i.e. inter-related models, describing different views on the DSML. These separate, yet inter-related models are potential sources of specification inconsistencies which bear a high risk of affec...

A Yersinia pestis-derived fusion protein (F1-V) has shown great promise as a protective antigen against aerosol challenge with Y. pestis in murine studies. In the current study, we examined different prime-boost regimens with F1-V and demonstrate that (i) boosting by a route other than the route used for the priming dose (heterologous boosting) protects mice as well as homologous boosting again...

IoT is considered as one of the key enabling technologies for the fourth industrial revolution that is known as Industry 4.0. In this paper, we consider the mechatronic component as the lowest level in the system composition hierarchy that tightly integrates mechanics with the electronics and software required to convert the mechanics to intelligent (smart) object offering well defined services...