Adenosine diphosphate (ADP) induced aggregation of rabbit platelets, without the release reaction, causes a significant decrease (7%) in the amount of phosphatidylinositol-4,5-bisphosphate (PIP2) at 10 sec and at 60 sec (11%). In platelets prelabeled with 32P-phosphate, this decrease in PIP2 is associated with a decrease in PIP2 radioactivity, which is significant at 50 sec. The decrease in PIP...

The phenol nerve block has been widely used in clinical practice for spasticity reduction, but the correlation between the dosage of phenol and its effectiveness has seldom been discussed. The objective was to determine the optimal duration of phenol in contact with the nervous tissue and to investigate the dose-response relationship of 5% aqueous phenol solution by percutaneous nerve block in ...

CONFLICT OF INTEREST NONE DECLARED The aim of the study was detection of diastolic dysfunction of myocardium with Tissue Doppler Imaging (TDI) in asymptomatic type 2 diabetic patients, in five years duration of disease, and normal cardiac function on conventional echocardiography (CE), according to the performance showed on exercise stress test. MATERIAL AND METHODS We studied 300 patients, o...

In this appendix we aim to provide additional results that could not be presented in the accompanying paper. The focus will be on cases that did not already provide satisfactory results but we will also present new examples where our algorithm matches the ground truth. We will show in Appendix Sec. 2 images of the Milk model with full illumination and provide a different light source configurat...

abstract background: bruising is an unpleasant result of subcutaneous injection of enoxaparin, which causes physical discomfort, limitation of injection site, patient’s refusal of treatment, and distrust in nurses’ ability. the application of techniques which reduce patients’ fear, anxiety, and physical damage is one of the tasks of nurses. this clinical trial investigated the effect of duratio...

BACKGROUND Intra-cardiac thrombus (ICT) and spontaneous echo contrast (SEC) are considered hypercoagulable and inflammatory conditions. We aimed to determine if high sensitivity C-reactive protein (CRP) and D-dimer (DD), in combination with variables of lower thrombotic risk (normal ejection fraction [NEF], sinus rhythm [NSR]), may predict the absence of ICT/SEC. METHODS AND RESULTS Consecuti...

The presence of an intramolecular hydrogen bond has been proposed to play a key role in the catalysis of amide isomerization by peptidylprolyl isomerases (PPIases), which are highly conserved and ubiquitous rotamase enzymes that catalyze the cis-trans isomerization of proline residues in peptides and proteins. We present herein kinetic and spectroscopic evidence that indicates the existence of ...

purpose: to evaluate the effect of laser in situ keratomileusis (lasik) on stereoacuity (sa). methods: in this prospective study, 200 patients scheduled for lasik were evaluated for sa preoperatively and one week and one and three months postoperatively by random dot test. patients with preoperative sa worse than 480 sec/arc were excluded. results: patients included 138 female (69%) and 62 male...