Introduction: The low regeneration of bone in defective bones causes therapeutic problems. Various strategies to assess the healing of bone defects have been used which they include histological and histo-chemical analysis in an invasive study. The purpose of this study was to determine the ultrasonic parameters of bone as a promising noninvasive technology for assessing bone repair process. Ma...

Sinusoidal obstruction syndrome (SOS; formerly veno-occlusive disease) is a well-established complication of hematopoietic stem cell transplantation, pyrrolizidine alkaloid intoxication, and widely used chemotherapeutic agents such as oxaliplatin. It is associated with substantial morbidity and mortality. Pathogenesis of SOS in humans is poorly understood. To explore its molecular mechanisms, w...

1174 I n order to survive in various environmental conditions, cells have a repertoire of genes that they can choose to express or silence according to their needs. Among this vast collection of genetically controlled networks, the SOS response is an inducible DNA repair system that allows bacteria to survive sudden increases in DNA damage. The importance of the SOS response is underscored by t...

Emerging applications are not just large-scale and complex; they are also characterized by decentralized, distributed, networked compositions of heterogeneous and (semi)autonomous elements. These new “systems” are, in fact, “systems of systems” (SoS) *1+. The term has arisen from the systems engineering community and reflects the interest in concepts and developments such as smart grids, integr...

Sos proteins function as activators of Ras signaling by catalyzing guanine nucleotide exchange on Ras. Sos regulation was initially thought to be accomplished primarily through its growth factor-dependent recruitment to the plasma membrane. More recent data has indicated that while membrane association is an indispensable means of Sos regulation, additional mechanisms involving intramolecular i...

In this work, a new hybrid Symbiotic Organisms Search (SOS) algorithm introduced to design and optimize spatial and planar structures under structural constraints. The SOS algorithm is inspired by the interactive behavior between organisms to propagate in nature. But one of the disadvantages of the SOS algorithm is that due to its vast search space and a large number of organisms, it may trap i...

Bacteriocins are a large and functionally diverse family of toxins found in all major lineages of Bacteria. Colicins, those bacteriocins produced by Escherichia coli, serve as a model system for investigations of bacteriocin structure-function relationships, genetic organization, and their ecological role and evolutionary history. Colicin expression is often dependent on host regulatory pathway...

Complex gene regulatory circuits exhibit emergent properties that are difficult to predict from the behavior of the components. One such property is the stability of regulatory states. Here we analyze the stability of the lysogenic state of phage λ. In this state, the virus maintains a stable association with the host, and the lytic functions of the virus are repressed by the viral CI repressor...

The paper attempts to formalise the loose concept of “System of Systems” (SoS) within the context of Systems Theory and explores and develops a conceptual framework for emergence that is suitable for further development. We view the notion of SoS as an evolution of the standard notion of systems and provide an abstract and generic definition that is detached from the particular domain. To achie...

Structured Operational Semantics (SOS) is a popular method for defining semantics by means of deduction rules. An important feature of deduction rules, or simply SOS rules, are negative premises, which are crucial in the definitions of such phenomena as priority mechanisms and time-outs. Orderings on SOS rules were proposed by Phillips and Ulidowski as an alternative to negative premises. The m...