Multiple cell cycle regulatory proteins play an important role in oncogenesis. Cancer cells may arise from dysregulation of various genes involved in the regulation of the cell cycle. In addition, cyclin-dependent kinase inhibitors are regarded as key regulators for cancer cell proliferation. Accordingly, permission of impaired cells by cell cycle checkpoints suppresses carcinogenesis. P53, a m...

Today, even the simplest laptop processor has at least four cores and a graph-ics card containing tens of cores. It is not hard to find more performance-oriented processors with hundreds of cores, and it is expected to see proces-sors with thousands of cores in the not very far future.In these and future processors, the design of the interconnection networkbetween the cores ...

Richard Bright in 1827 described it as typhis fever with bowel complications. The typhus group of fevers was houn e y uncertain landmarks until Jenner in IBM nrs established the essential pathological difference, between typhus and typhoid fever, on the basis ?f the lesions in the small intestine. The clinical manifestations of the r0P ' fevers, with the many and varied comp ica 1 prevalent in ...

Sulfite, produced for instance during amino acid metabolism, is a very reactive and toxic compound. Various detoxification mechanisms exist, but sulfite oxidoreductases (SORs) are one of the major actors in sulfite remediation in bacteria and animals. Here we describe the existence of an operon in the extreme thermophilic bacterium Thermus thermophilus HB8 encoding both a SOR and a diheme c-typ...

Public unease about industry’s influence over clinical research has never been greater. Recent events have elevated concerns about financial ties among investigators, academic medical centers, and industry sponsors,1-4 and disquieting findings have emerged about the legal relationships these entities form to conduct clinical trials.5-8 Tort liti­ gation brought by injured research subjects has ...

OBJECTIVES The incidence of lung cancer in Koreans is increasing in women and in both men and women with a never-smoking history. Human papillomavirus (HPV) infection has been suggested as a modifiable risk factor of lung cancer in never-smokers and women (LCNSW). This systematic review (SR) aimed to evaluate an association between HPV infection and lung cancer risk in LCNSW. METHODS Based on...

To date, several activating mutations have been discovered cells and hence investigate their oncogenic potential, we in the common signal-transducing subunit (hbc) of the rehave expressed all three mutants in primary murine hematoceptors for human granulocyte-macrophage colony-stimupoietic cells using retroviral transduction. It is shown that, lating factor, interleukin-3, and interleukin-5. Tw...

OBJECTIVES To agree terminology and to develop recommendations for the diagnosis of calcium pyrophosphate deposition (CPPD). METHODS The European League Against Rheumatism (EULAR) CPPD Task Force, comprising 15 experts from 10 countries, agreed the terms and recommendations for diagnosis of CPPD using a Delphi consensus approach. Evidence was systematically reviewed and presented in terms of ...

The nonmetastatic neutrophilia-inducing murine mammary carcinoma CE 1460 has been shown previously to have profound effects on hemopoiesis and lymphopoiesis. In this report we examined the effects of progressive growth of CE1460 on natural killer (NK) cell activity both in the bone marrow, the site of primary NK cell production, and in a peripheral site, the spleen. (BALB/c x CE)Fi mice were in...