Background Both light-chain (AL) amyloidosis and transthyretin (ATTR) are types of cardiac (CA) that require accurate prognostic stratification to plan therapeutic strategies follow-ups. Cardiac biomarkers, e.g., N-terminal pro-B-type natriuretic peptide (NT-proBNP) high-sensitivity troponin T (Hs-cTnT), remain the cornerstone assessment. An increased level soluble suppression tumorigenesis-2 (...

INTRODUCTION ST2 is a member of the interleukin (IL)-1 receptor family, and IL-33 is its natural ligand. ST2 signaling promotes Th2 immune response in allergy, autoimmunity, and chronic inflammatory disorders, but its role in the pathogenesis of periapical lesions is unknown. The purpose of this study was to investigate whether ST2 gene deletion affects the development of experimentally induced...

Interleukin-33, a ligand for ST2/T1, has an important role in allergy, autoimmunity and inflammation. The role of IL-33/ST2 axis in cancer is not elucidated. Using metastatic breast cancer model we provide evidence that lack of ST2 signaling led to reduced tumor growth and metastasis and enhanced anti-tumor immunity.

Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced signif...

BACKGROUND The prognosis in patients with chronic heart failure (CHF) is poor. ST2 protein is a promising prognostic biomarker for CHF. ST2 belongs to the cardioprotective signalling pathway involving interleukin-33 and its concentration in the serum depends on the biomechanical stress of cardiomyocytes (biomechanical strain). AIM To determine the prognostic value of ST2 in short term follow-...

Toll like receptors (TLR) čine familiju transmembranskih signalnih proteina koji delujući kao senzori za produkte mikroorganizama započinju antimikrobni imunski odgovor. Do danas, kod sisara je poznato 12 TLR gena koji kodiraju isto toliko membranskih glikoproteina sa ekstracelularnim delom bogatim leucinom i intercitoplazmatskim delom sa homologijom (TIR). Toll-IL-1 receptor (TIR) domen sadrži...