Abstract In this work, solubility of hydrogen in some alkenes was investigated at different temperatures and pressures. Solubility values were calculated using the Peng–Robinson equation state. Binary interaction parameters fitting state on experimental data, Group contribution method Moysan correlations total average absolute deviation for these methods 3.90, 17.60 13.62, respectively. Because...

Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limita...

The purpose of this work was to construct a consensus prediction algorithm of 'aggregation-prone' peptides in globular proteins, combining existing tools. This allows comparison of the different algorithms and the production of more objective and accurate results. Eleven (11) individual methods are combined and produce AMYLPRED2, a publicly, freely available web tool to academic users (http://b...

Introduction. The Center for Eukaryotic Structural Genomics is dedicated to determining the structures of novel proteins from eukaryotic organisms. Open reading frames are scored using thirteen different categories (i.e. new fold prediction, solubility prediction, small percentage of low complexity sequence, etc.) and then ranked to indicate their suitability for study bynuclearmagnetic resonan...

Group contribution methods such as the UNIFAC are of major interest to researchers and engineers involved synthesis, feasibility studies, design and optimization of separation processes as well as other applications of industrial use. Reliable knowledge of the phase equilibrium behavior is crucial for the prediction of the fate of the chemical in the environment and other applications. The obje...