Little information is currently available regarding bloodstream infection (BSI) in patients with solid tumors who, for a variety of reasons, are particularly predisposed to develop this condition. In this review we focus on the incidence, epidemiology, clinical features, etiology, antimicrobial resistance, and outcomes of BSI of adult cancer patients with solid tumors. Most episodes of BSI occu...

Since the original work of Fleming (1), many antibiotics have been isolated from culture filtrates of soil microorganisms. A few of the antibiotics have demonstrated anti-tumor effects in experimental animals (9, 25). Recently, Hata and his associates (8, 12), Sakai and Teranaka (11), and Teranaka (29) reported that mitomycin C, a new antibiotic isolated from Streptomyces caespitosus (4), has s...

PURPOSE Using pathologically proven tumors and 3 methods of apparent diffusion coefficient (ADC) measurement, we examined the potential of diffusion-weighted imaging (DWI) to differentiate adrenal tumors. METHODS We evaluated adrenal tumors of 52 patients who underwent magnetic resonance (MR) examination including DWI and adrenal resection or biopsy between July 2006 and August 2011. Tumors i...

Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown clinical activity in patients with germline BRCA1/2 mutation (gBRCAm)-associated breast and ovarian cancers. Accumulating evidence suggests that PARPi may have a wider application in the treatment of cancers defective in DNA damage repair pathways, such as prostate, lung, endometrial, and pancreatic cancers. Several PARPi are currently i...

Recent years, we have witnessed significant progresses in both basic and clinical studies regarding novel therapeutic strategies with genetically engineered T cells. Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. However, targeting solid tumors is more challenging than targeting B-cell...

Response Evaluation Criteria for Solid Tumours (RECIST) were introduced in 2000 to provide a standardized method for assessing response to treatments. The RECIST Working Group has updated RECIST to Version 1.1.

There have been a number of major advances in imaging technology in recent years. Here we discuss in detail multislice CT and PET, since these are the two modalities generating the most interest in cancer imaging, but which also have the potential for significantly increasing the radiation burden in the paediatric population. In addition, we focus on the implications of the new Response Evaluat...

BACKGROUND To quantify the long-term risk of second cancers (SCs) up to 30 years after primary treatment for Hodgkin's disease (HD) Material and methods In the period 1968 to 1985, an unselected population of 1024 patients started treatment for HD at the Norwegian Radium Hospital (NRH) and were followed for SC from 1969 through 1998 by The Norwegian Cancer Registry. The median age at diagnosis ...

  This is a rare case report of bilateral Schwannoma in lower poles of both kindeys in a 36 year old diabetic man.preoperative radiographic evaluations suggested the presence of two solid retroperitoneal tumors attached to the lower poles of both kindeys without any regional or distant extension.the final diagnosis was confirmed by histological and immonohistological studies.

Fanconi anemia (FA) is an autosomal recessive condition associated with congenital abnormalities, progressive pancytopenia, and a predisposition to leukemia and solid tumors. We studied a retrospective cohort of North American patients with FA. We calculated relative risks of cancer compared to the general population and cause-specific hazards of the first major adverse outcomes of FA: bone mar...