INTRODUCTION Solid and cystic pseudopapillary tumor of the pancreas is a rare tumor of the pancreas, for the first time described by Frantz et al. in 1959. The majority of patients are young females and most of them are asymptomatic. CASE OUTLINE We report a case of 25-year old woman who was admitted to our institution with abdominal pain and a palpable mass in the left hypochondrial area. US...

Angiogenesis or the generation of new blood vessel, is an important factor in the growth of a solid tumor. Hence, it becomes a necessary parameter of any kind of therapeutic study. Glutamine is an essential nutrient of tumor tissue and glutamine related therapy involves clearance of circulatory glutamine by glutaminase. Therefore, using different murine solid tumor models, the present study was...

In mathematical cancer modeling, the growth of solid tumors combines the mechanics of cell-cell adhesion, cell growth velocity and angiogenesis amongst numerous others. This project simulates solid tumoral growth with the use of a coupled system of Cahn-Hilliard-type convection-reaction-diffusion equations. This mathematical model uses a two-cellular tumoral structure of viable, or proliferatin...

Genetic and epigenetic events within a cell which promote a block in normal development or differentiation coupled with unregulated proliferation are hallmarks of neoplastic transformation. Differentiation therapy involves the use of agents with the ability to induce differentiation in cells that have lost this ability, i.e. cancer cells. The promise of differentiation-based therapy as a viable...

FIZZ:: case repon on a ram inUaaular tumor. A 34 years old female plienl hat a ITat pigmented subconjunctival spa at 3 o’clock 3mm behind the limbus of her left eye for many years. Accidentally B Mafk tumor of tie ciliary body was seen at 5 o’clock. Visual acuity w 13 on bXh eyes. The irmmcular tumor tag&r with b &ml perforation was mated bu local rsection. Histology will be presented tog&w wit...

Download cular endothelial growth factor and its receptors, including Flt-1 and Flk-1, are involved in angiogenesis physiologic and pathologic conditions. Recently, Flt-1–expressing cells were reported to contribute to racranial growth of glioma cells. However, the role of Flt-1 signaling in solid tumor growth in s.c. tissue t been elucidated. To investigate how Flt-1 signaling is involved in t...

JEM © The Rockefeller University Press $15.00 Vol. 204, No. 2, February 19, 2007 345–356 www.jem.org/cgi/doi/10.1084/jem.20061890 345 T cell–mediated immune responses require the active migration of T cells in tissues and the establishment of specifi c cell–cell contacts with other cell types. T cell migration was analyzed intravitally in the last few years using noninvasive two-photon microsco...

PURPOSE Hypoxia is an important characteristic of the solid tumor microenvironment and constitutes a barrier for effective radiotherapy. Here, we studied the effects of darinaparsin (an arsenic cytotoxin) on survival and radiosensitivity of tumor cells in vitro under normoxia and hypoxia and in vivo using xenograft models, compared to effects on normal tissues. EXPERIMENTAL DESIGN The cytotox...

The problem of the onset and growth of solid tumour in homogeneous tissue is regarded using an approach based on local interaction between the tumoral and the sane tissue cells. The characteristic sizes and growth rates of spherical tumours, the points of the beginning and the end of spherical growth, and the further development of complex structures (elongated outgrowths, dendritic structures,...