Gliclazide is a second-generation hypoglycaemic sulfonylurea that is useful in the treatment of Type 2 diabetes mellitus. It shows low aqueous solubility and dissolution rate and often shows low and irregular bioavailability after oral administration. This paper describes an approach to improve the Solubility of gliclazide by using solid dispersions (SDs) in polyethylene glycol 4000 (PEG 4000)....

The present study aimed to investigate the effect of Eudragit® E/HCl (E-SD) on the degradation of sirolimus in simulated gastric fluid (pH 1.2) and to develop a new oral formulation of sirolimus using E-SD solid dispersions to enhance oral bioavailability. Sirolimus-loaded solid dispersions were fabricated by a spray drying process. A kinetic solubility test demonstrated that the sirolimus/E-SD...

PURPOSE The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties. METHODS Polyvinylpyrrolidone (PVP), Poloxamer 188 and Cremophore RH40 were used to prepare the solid dispersions of sirolimus. In vitro dissolution study using USP type I apparatus, were performed in distilled ...

ni6(n2h4)6(so4)4(oh)2(h2o)8](so4)(h2o)10 complex was prepared according to literature report. the reaction between aforementioned complex via sodium alkoxides as a reactants, were carried out in the solid state. the [ni6(n2h4)6(so4)4(oh)2(h2o)8](so4)(h2o)10 undergoes an intramolecular two electrons oxidation-reduction reaction at room temperature and metallic nickel nanoparticles (ni1-ni5) was ...

ni6(n2h4)6(so4)4(oh)2(h2o)8](so4)(h2o)10 complex was prepared according to literature report. the reaction between aforementioned complex via sodium alkoxides as a reactants, were carried out in the solid state. the [ni6(n2h4)6(so4)4(oh)2(h2o)8](so4)(h2o)10 undergoes an intramolecular two electrons oxidation-reduction reaction at room temperature and metallic nickel nanoparticles (ni1-ni5) was ...